Champions League matchday four features several tantalizing fixtures, but none will catch the eye more than Liverpool vs Real Madrid on Tuesday, November 4. The kickoff is scheduled for 3 p.m. ET at Anfield. The Reds are in poor form, but they finally won a match in the Premier League over the weekend, beating Aston Villa. As for Los Blancos, they cruised in LaLiga play on Saturday, and have yet to drop a single point in Europe’s most prized competition. Read on for the Liverpool vs Real Madrid picks.
Champions League: Liverpool vs Real Madrid Odds, Analysis, & Picks

Photo courtesy of Ruraidh Gillies (Flickr), CC by 2.0
Highlights
- Liverpool and Real Madrid meet on Tuesday at Anfield
- There’s no clear favorite for this UCL affair
- Keep reading for the odds, preview, and picks
Odds courtesy of Sports Interaction.
Liverpool vs Real Madrid Odds
| Moneyline | Liverpool +155 | Real Madrid +145 |
| Total Goals | Ov 3.5 (+100) | Un 3.5 (-135) |
Madrid has +145 moneyline odds for this fixture at Canadian sportsbooks. Liverpool returns at +155 as they look for a crucial three points on home soil.
These two have met 12 times in the Champions League, with the Reds winning seven games. Madrid has captured four victories of their own, while the other clash ended level. Most recently, Liverpool ran out 2-0 winners at Anfield in last season’s group stage.
Liverpool vs Real Madrid Analysis
The Reds started the 2025-26 campaign in exhilarating form, looking the part of a side that could go all the way domestically and continentally. But, ever since a 2-1 defeat to Crystal Palace on September 27, it’s been a nightmare for Liverpool fans. Arne Slot’s men have lost six of their last eight matches across all competitions, and that includes a 1-0 defeat to Galatasaray on matchday two.
But the Merseysiders bounced back on matchday three two weeks ago, smashing Eintracht Frankfurt 5-1 in Germany. Two more losses followed to Brentford in the EPL and then Palace in the League Cup, but Liverpool finally won again in league action on Saturday as they blanked Villa. Mo Salah and Ryan Gravenberch produced the goods in front of goal, helping the Reds move up to third place in the table. In the Champions League, they’re 10th in the standings with a 2-1-0 record, also beating Atletico Madrid on matchday one on Merseyside.
Madrid has no shortage of motivation this term after failing to win a trophy last season, and they’re certainly showing a hunger to dominate. Xabi Alonso’s side is 10-0-1 in LaLiga and five points clear of Barcelona at the top. Aside from a shock 5-2 defeat in the Madrid derby, Los Blancos have been essentially flawless in Spain. Kylian Mbappe is absolutely flourishing, already bagging 13 goals in 11 LaLiga appearances. He’s also firing on all cylinders in Europe, scoring five in three games.
Real is one of five clubs in the Champions League that own a perfect record heading into matchday four. They’ve scored eight times while conceding just once. Los Blancos have beaten Juventus, Marseille, and Kairat up until this point. While Liverpool will be a difficult task, Madrid is facing the Premier League giants at an ideal time as they struggle to string together consistent results.
Liverpool vs Real Madrid Injury News
Slot has health concerns on Tuesday. Alexander Isak and Curtis Jones are unlikely to feature due to injury, while Allison Becker, Jeremie Frimpong, and Giovanni Leoni remain sidelined. Alonso’s backline will be tested, with the visitors without key defenders David Alaba, Antonio Rudiger, and Dani Carvajal.
Liverpool vs Real Madrid Picks
One win isn’t enough to convince me Liverpool can topple a side in Madrid’s form right now. I’ll take the visitors to leave Anfield with three points, though the Reds should find the back of the net.
Pick: Madrid to win & both teams to score +210 (Sports Interaction)
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Quinn Allen is a sports writer from Vancouver, Canada. His expertise spans across many sports, but he tends to write mostly European soccer betting previews for BettingTop10 Canada. He’s been in the industry for seven years. Quinn loves to be active in his free time, whether it’s working out, walking, or playing soccer.

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