NFL Week 4 Late Sunday 4PM Betting Odds & Best Bets

Week 3 wasn’t what you’d call a banner week for us and our late game picks. After going 4-1 in Week 2, we crashed back down to earth with a 1-2 day in Week 3. Christian McCaffrey finally came through for us to save our week, but Justin Jefferson was injured, which voided his prop. Also, the Saints (and everyone else) were shocked by the Raiders and in Brazil, they had no regard for our under.

But as always, we move. Week 4 brings us a four-game slate with three inter-conference games and an AFC West showdown on the Vegas Strip. We’ve got a best bet for each one, and we’re hungry for a bounce back week. Read on for our picks and the top betting odds from the best Ontario betting sites. 

2026 Late Sunday 4PM Best Bets: 7-5 (+0.85)
2025 Late Sunday 4PM Best Bets: 22-14 (+2.81)

NFL Week 4 Late Sunday 4PM Betting Odds & Best Bets

All betting odds provided by Betway.

Miami Dolphins (0-3) @ Minnesota Vikings (3-0) - 4:05PM

The Miami Dolphins have been beaten by double digits in each of their three losses to start the season. But their defence is actually not as bad as it seems. We love the Vikings here, but the spread is a little too rich for our blood. Aaron Jones and Jordan Addison both have enticing receiving props, but if the Vikings get up big early, they could simply stop throwing.

On the other hand, we expect a lot of pass plays from Miami–and a lot of blitzing from the mad man Brian Flores, who will no doubt want to leave a mark on the team that he sued after they fired him way back when. If you can find it on your book, take the Vikings to get over 4.5 sacks. They lead the league with 14 sacks and a 66+ blitz rate. The Dolphins have given up nine sacks. Dallas Turner to get a sack at -260 is also a good bet, though not one offering a ton of value.

Best Bet: Minnesota Vikings Over 4.5 Sacks (-110)

Los Angeles Chargers (0-3) @ Seattle Seahawks (2-1) - 4:25PM

The Los Angeles Chargers remain a quandary. We never thought they’d be great this season, but we still don’t think they’re as bad as they’ve played so far. And yet, a road date with the defending champs looking to bounce back from an embarrassing loss in Week 3 is a terrible spot for them. Again, the spread is too big here, so we’ll go with the tight end A.J. Barner, who had nine targets and 69 yards last week as he proved his chemistry with the returning Sam Darnold.

Best Bet: A.J. Barner 30+ Receiving Yards (-110)

Denver Broncos (2-1) @ San Francisco 49ers (3-0) - 4:25PM

The injury bug simply will not leave the 49ers alone. It has once again claimed Nick Bosa, and several other key players are questionable. However, they seem to be trending in the right direction. Trent Williams is off the injury report, and Mike Evans and Dre Greenlaw were limited in practice. The most important thing is they still have Brock Purdy and Christian McCaffrey. They like to play at home, where they are 10-5 straight up as favourites since 2024.

Best Bet: San Francisco 49ers Moneyline (-144)

Kansas City Chiefs (3-0) @ Las Vegas Raiders (3-0) - 4:25PM

A Week 4 matchup of undefeated teams between the Chiefs and Raiders. Just like we drew it up. We have a feeling the Chiefs might finally show what a fraud Las Vegas is, but with this being a divisional game, we still bought a few points down. If K.C.’s moneyline was just a little bit cheaper we would’ve been all over that.

Best Bet: Kansas City Chiefs Alternate -2.5 Point Spread (-180)