NFL Week 6 Late Sunday 4PM Betting Odds & Best Bets

We had a couple of absolutely brutal bad beats last week during the late 4PM slate. Jacoby Brissett came through for us, but Omarion Hampton and Emanuel Wilson fell short of their props by a combined five yards.

When it happens like that, all you can do is channel your inner Tony Soprano and say: waddyagonnado? We’re still keeping our heads above water, but we think we’re due for a couple of lucky bounces to go our way here in Week 6.

This week we like a potent QB against a terrible pass defence, the best tight end in football, and perhaps the best running back in football right now. Read on for our best bets on each of the three late Sunday 4PM matchups for Week 6 as well as the latest NFL betting odds from the top betting sites!

2026 Late Sunday 4PM Best Bets: 10-9 (-0.99)
2025 Late Sunday 4PM Best Bets: 22-14 (+2.81)

NFL Week 6 Late Sunday 4PM Betting Odds & Best Bets

All betting odds provided by Betway.

Arizona Cardinals (1-4) @ Los Angeles Rams (3-2) - 4:05PM

The Cardinals have been reeling since that Week 1 upset win. They have lost three of their last four games by double digits, but with this being a divisional tilt, you never can be too careful. What we know for sure is that their defence has more holes than a Shia Labeouf movie.

They have allowed 14 touchdowns through the air so far, tied for the most in football. And again, it’s been especially bad over the last four weeks: Drew Lock, Jared Goff, and Jameis Winston all threw three TDs against this defence, and Brock Purdy threw four.

Matthew Stafford has thrown zero touchdowns in two games this year, surprisingly enough, but he’s thrown 3+ in two as well. He’s got the best wideout duo in football and an opposing defence akin to a leaky faucet. We couldn’t say no to these plus (+) odds either.

Best Bet: Matthew Stafford Over 2.5 Pass TDs (+106)

Buffalo Bills (4-1) @ Las Vegas Raiders (3-2) - 4:25PM

Since returning from injury, Brock Bowers has been one of the most dominant offensive forces in the NFL. He’s had 6+ receptions, 85+ receiving yards, and a TD in all three of his starts so far this year, and now he gets to take on one of the worst defences in the league. And at home too.

Buffalo has given up 13 touchdowns through the air this year, fourth-most in the NFL. They've actually only given up one touchdown to tight ends this season, but we think Bowers is more of a tight end-wide receiver hybrid anyway. We think Bowers will find pay dirt for the fourth straight game.

Best Bet: Brock Bowers Anytime Touchdown Scorer (-115)

Los Angeles Chargers (0-5) @ Kansas City Chiefs (4-0) - 4:25PM

Kenneth Walker III has been one of the most impactful offseason additions in the NFL this year. He’s rushed for 110+ yards in three of his four games, and he’s scored in three of four as well. Now he gets the wandering and winless Chargers coming into his house at Arrowhead.

L.A. hasn’t been terrible against the run, they’re giving up just a hair under 100 yards per game on the ground to RBs, which ranks in the middle of the pack. Walker and the Chiefs offence will score on the Chargers, and that will put them in a positive game script which will allow Walker to hit 20 carries in this one. Every time he’s had 20+ carries this year, he’s gone for 100+ yards.

Best Bet: Kenneth Walker III 90+ Rush Yards (-120)