NFL Week 10 Sunday Pick 'Em All: Winners & Betting Odds

Pickpik
We’ve got 12 games on the NFL Sunday slate for Week 10 as we open up the second half of the 2026 campaign. The trade deadline was busier than usual, so we’re going to see a lot of new faces in new places for the first time come Sunday. Read on for our picks and the latest odds from the top online sportsbooks!
Highlights
- All picks are made straight up, not against the spread
- There are 12 NFL games this Sunday, going from the 1pm slate to SNF in America’s capital
- Parlay odds for all our picks: +29,594 odds, $10 bet pays $2,959.45
NFL Week 10 Pick ‘Em All Betting Odds & Picks
All betting odds provided by Betway.
New England Patriots (5-4) @ Detroit Lions (6-2) - 9:30AM (MUNICH, GERMANY)
| Team | Moneyline | Point Spread |
| New England Patriots | +124 | +2.5 (-110) |
| Detroit Lions | -146 | -2.5 (-110) |
You never can tell with a game out in Europe, but the Lions are the more talented team, and if anything travels, it’s talent. Patriots QB Drake Maye has not looked great over the last few weeks either.
Pick ‘Em All Pick: Lions (-146)
Minnesota Vikings (6-2) @ Green Bay Packers (6-3) - 1PM
| Team | Moneyline | Point Spread |
| Minnesota Vikings | +138 | +2.5 (-110) |
| Green Bay Packers | -164 | -2.5 (-110) |
The Kirk Cousins addition will be a boon for more than just Justin Jefferson. It’s going to improve the Vikings immensely. But not this week. The Packers are rolling, and they’re at home. Don’t overthink this one.
Pick ‘Em All Pick: Packers (-164)
Houston Texans (3-5) @ Cleveland Browns (5-4) - 1PM
| Team | Moneyline | Point Spread |
| Houston Texans | -235 | -4.5 (-110) |
| Cleveland Browns | +194 | +4.5 (-110) |
The wheels are starting to come off in Cleveland. It’s a familiar feeling, it’s just happening later in the season than it usually does. We think Shedeur Sanders is a decent signal caller, but the Texans are still in a must win situation. 3-6 would pretty much be a death knell for them playoff-wise.
Pick ‘Em All Pick: Texans (-235)
Kansas City Chiefs (6-2) @ Atlanta Falcons (3-6) - 1PM
| Team | Moneyline | Point Spread |
| Kansas City Chiefs | -174 | -3.5 (-110) |
| Atlanta Falcons | +146 | +3.5 (-110) |
We’re not really sure why this line is so tight. The Chiefs are 6-2 and the Falcons have been one of the most erratic teams in the league this season. They haven’t looked confident in a while. Expect a big game from Kenneth Walker III.
Pick ‘Em All Pick: Chiefs (-174)
Miami Dolphins (1-7) @ Indianapolis Colts (2-7) - 1PM
| Team | Moneyline | Point Spread |
| Miami Dolphins | +180 | +3.5 (-110) |
| Indianapolis Colts | -215 | -3.5 (-110) |
The Colts were big sellers at the trade deadline, but they did keep Daniel Jones and Jonathan Taylor. For whatever that’s worth with the rest of the roster cleaned out. The Dolphins are a sneaky upset pick this week. Whenever you can get near +200 odds on a team playing the Danny Dimes Colts, you should take it.
Pick ‘Em All Pick: Dolphins (+180)
Jacksonville Jaguars (6-2) @ Tennessee Titans (1-7) - 1PM
| Team | Moneyline | Point Spread |
| Jacksonville Jaguars | -700 | -10.5 (-110) |
| Tennessee Titans | +500 | +10.5 (-110) |
The only reason this spread isn’t like 17 points is because it’s a divisional game. Tennessee won’t be the upset team this week, though we think they could cover. Divisional game and all.
Pick ‘Em All Pick: Jaguars (-700)
Carolina Panthers (3-5) @ New Orleans Saints (3-5) - 1PM
| Team | Moneyline | Point Spread |
| Carolina Panthers | +110 | +2.5 (-110) |
| New Orleans Saints | -130 | -2.5 (-110) |
Another tough divisional game to call, but we’re leaning the Panthers on the road. Both of these teams struggle defensively, but we think Bryce Young is superior to Tyler Shough. Nuff said.
Pick ‘Em All Pick: Panthers (+110)
Buffalo Bills (7-1) @ New York Jets (2-7) - 1PM
| Team | Moneyline | Point Spread |
| Buffalo Bills | -480 | -7.5 (-110) |
| New York Jets | +370 | +7.5 (-110) |
This is another surprisingly small spread. The Bills played on Monday and they’re on the road and it’s a divisional game. So maybe. But there’s no way Aaron Glenn wins this one outright.
Pick ‘Em All Pick: Bills (-480)
Los Angeles Rams (5-4) @ Arizona Cardinals (3-6) - 4:05PM
| Team | Moneyline | Point Spread |
| Los Angeles Rams | -550 | -9.5 (-110) |
| Arizona Cardinals | +410 | +9.5 (-110) |
The Rams have been one Arizona Cardinals of the least confident favorites this season, and we wouldn’t bet this one straight up. But we just can’t imagine L.A. allowing themselves to fall back to .500 for the rest of the season.
Pick ‘Em All Pick: Rams (-550)
Seattle Seahawks (5-4) @ Las Vegas Raiders (4-5) - 4:05PM
| Team | Moneyline | Point Spread |
| Seattle Seahawks | -290 | -6.5 (-110) |
| Las Vegas Raiders | +235 | +6.5 (-110) |
Drew Lock seems like he’ll be good to go for this one, and that’s fine by Seattle. We’re not sure he’s a step down from the starter considering how Sam Darnold played in the last few games before his injury.
Pick ‘Em All Pick: Seahawks (-290)
San Francisco 49ers (7-1) @ Dallas Cowboys (4-5) - 4:25PM
| Team | Moneyline | Point Spread |
| San Francisco 49ers | -210 | -4.5 (-110) |
| Dallas Cowboys | +176 | +4.5 (-110) |
This is a classic NFL matchup. Joe Montana Danny White. Troy Aikman Steve Young. Terrell Owens. Dwight Clarke. Charles Haley. We think this is going to be another titillating chapter in this rivalry. But the 49ers are clearly superior at the moment. You just can’t trust that Dallas defence.
Pick ‘Em All Pick: 49ers (-210)
Pittsburgh Steelers (6-2) @ Cincinnati Bengals (6-2) - 8:20PM
| Team | Moneyline | Point Spread |
| Pittsburgh Steelers | +156 | +3.5 (-110) |
| Cincinnati Bengals | -186 | -3.5 (-110) |
The Steelers won a thriller in the reverse matchup earlier this season, so the Bengals will be looking for revenge. They seem like a bit of a paper tiger to us though: during their four-game win streak, they’ve beaten Michael Penix Jr., Cam Ward, Snoop Huntley/Joe Fagnano, and Malik Willis. Pittsburgh can win this as a road dog.
Pick ‘Em All Pick: Steelers (+156)
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Alex Murray has been a consistent presence on BettingTop10 since he joined the team in 2020 just after graduating from Ryerson University’s Sport Media program in 2019. He has written for publications including theScore, Sporting News, FanSided, FantasyPros, and more over his 6+ years in the field. Alex has also been a lifelong athlete and sports fan who has channeled that love into his entertaining writing style and shrewd betting strategies.

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