US Open: Alexander Blockx vs Karen Khachanov Odds, Analysis, & Picks

Photo courtesy of jpellgen (Flickr), CC by 2.0
Alexander Blockx and Karen Khachanov clash on Wednesday in the US Open quarterfinals at the USTA Billie Jean King National Tennis Center. The 21-year-old Blockx continued his breakout run by beating No. 24 seed Francisco Cerundolo in four sets on Monday, having previously stunned No. 5 seed Flavio Cobolli in the third round. Khachanov had a much tougher path through the fourth round, battling back to beat No. 14 seed Learner Tien in five sets after cruising past Benjamin Bonzi in straight sets. Read below for our Blockx vs Khachanov picks.
Highlights
- Alexander Blockx and Karen Khachanov meet in the US Open quarterfinals on Wednesday
- Blockx is playing in his first career Grand Slam quarterfinal
- Keep reading for the odds, preview, and picks
Odds courtesy of TonyBet.
Alexander Blockx vs Karen Khachanov Odds
Khachanov is a clear -182 moneyline favorite at tennis betting sites. Blockx, meanwhile, sits at +135 odds.
Surprisingly, this is their first-ever meeting.
Blockx vs Khachanov Analysis
Blockx is enjoying the best season of his young career, and his remarkable run in New York has taken his breakthrough to another level. The 21-year-old Belgian has compiled a 37-16 record across all levels in 2026 and entered the US Open ranked inside the top 40 after starting the year well outside that territory. Blockx has been particularly effective on hard courts, and he's now reached his first career Grand Slam quarterfinal. Most impressively, he hasn't simply benefited from a favorable draw. The Belgian has already knocked off two seeded opponents at Flushing Meadows and has shown the ability to maintain an aggressive level over best-of-five matches.
Blockx cruised through his opening match against Marcelo Tomás Barrios Vera in straight sets before beating Marco Trungelliti in four. His biggest statement came in the third round against No. 5 seed Flavio Cobolli. After dropping the opening set in a tiebreak, Blockx responded by winning the next three, including a dominant 6-0 third set. He then backed up that upset by beating No. 24 Francisco Cerundolo 6-3, 4-6, 7-5, 7-5 in the fourth round. The Belgian has dropped only three sets across four matches and has looked increasingly comfortable on the big stage. Khachanov represents another step up in terms of Grand Slam experience, but Blockx has already proven he can handle top-notch opponents.
Khachanov arrived in New York in very different form. The veteran had lost his opening match at each of his three US Open tune-up tournaments and entered the final Major of ‘26 ranked around No. 50 on the Tour. However, the former top-10 player has rediscovered his best tennis when it matters. Khachanov is a proven performer at majors, having previously reached the semifinals of the US Open in 2022, and his run this summer marks his seventh career Grand Slam quarterfinal. His biggest victory came in the second round, when he recovered from losing the opening set to eliminate Canadian star Felix Auger-Aliassime in four sets.
Since then, Khachanov has continued to build momentum. He comfortably dispatched Benjamin Bonzi 6-3, 6-2, 6-4 in the third round before surviving his toughest test against No. 14 seed Learner Tien. Khachanov trailed two sets to one but bounced back with authority, winning the fourth set 6-1 before taking the decider 6-4 in a match lasting nearly four hours. His powerful serve and heavy baseline game have been clicking in New York, while his ability to battle through adversity against Tien showed why his experience could be a major advantage against Blockx.
Alexander Blockx vs Karen Khachanov Picks
Blockx is playing phenomenal tennis, but Khachanov tends to find his best in these Majors, specifically the US Open. He’s performed on this stage before, and I’ll take the Russsian to end the Belgian’s Cinderella run. His experience will prove to be key.
Quinn Allen is a sports writer from Vancouver, Canada. His expertise spans across many sports, but he tends to write mostly European soccer betting previews for BettingTop10 Canada. He’s been in the industry for seven years. Quinn loves to be active in his free time, whether it’s working out, walking, or playing soccer.

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