Premier League: Manchester City vs Crystal Palace Odds, Analysis, & Picks

Quinn Allen
By: Quinn Allen
Soccer Picks
Photo courtesy of Smabs Sputzer (Flickr), CC by 2.0

Photo courtesy of Smabs Sputzer (Flickr), CC by 2.0

The title race continues to be fierce, and Manchester City will be looking to gain ground on Arsenal on Wednesday when they welcome Crystal Palace to the Etihad Stadium. The kickoff is scheduled for 3 p.m. ET. The Cityzens are coming off a convincing 3-0 victory over the weekend against Brentford, while the Eagles’ winless run in England continued, settling for a 2-2 draw with Everton. Read on for the Manchester City vs Crystal Palace picks.

Highlights

  • Man City and Crystal Palace clash on Wednesday
  • City is a massive home favorite
  • Keep reading for the odds, preview, and picks

Odds courtesy of TonyBet.

Manchester City vs Crystal Palace Odds

City is a massive -477 moneyline favorite at soccer betting sportsbooks. Palace returns as a +1200 road underdog. A draw is priced at +640, while the O/U is set at 2.5 goals.

While the Sky Blues lost to the Eagles in the FA Cup showpiece last season, they won the reverse fixture at Selhurst Park. The hosts have tasted defeat just twice in their last 10 meetings with Crystal Palace across all competitions.

Manchester City vs Crystal Palace Analysis

City still has a shot at the treble this term, with the FA Cup final coming up, while they have already won the Carabao Cup. The Premier League title is undoubtedly the No. 1 focus, but they cannot afford a single slip-up as the campaign draws to a close this month. Pep Guardiola’s side is five points behind Arsenal with a game in hand, which means a victory here would move them within two points of the North London giants.

The Cityzens are unbeaten across their last eight games, winning seven of those matches. A 3-3 draw with Everton last Monday put them back in the title race after beating Arsenal late last month. Nevertheless, City responded on Saturday at the Etihad, running riot on Brentford. They absolutely battered the Bees’ net, registering 25 shots, and 10 on target. Erling Haaland, Jeremy Doku, and substitute Omar Marmoush all hit the back of the net. The Sky Blues have only tasted defeat once on home soil this term.

Palace may be in 14th place, but they’re set to play in the Conference League final later this month after beating Ukrainian behemoths Shakhtar Donetsk 5-2 in the semifinals. A first-ever European final is a serious feather in the Eagles’ cap, but they will still be hoping to fight their way into the Premier League top-10.

Oliver Glasner’s men have compiled an 11-11-13 record this term, and scoring goals has been an issue. They’ve netted just 38 times in 35 games while conceding 44. Palace have scored just twice across their last two games, and it won’t be any easier to create attacking opportunities against a strong City backline. Jean-Philippe Mateta and Ismaila Sarr both found the back of the net in a hard-fought draw with the Toffees. The Eagles have a 7-2-8 record away from Selhurst Park in 2025-26.

Manchester City vs Crystal Palace Injury News

For Manchester City, Abdukodir Khusanov remains a doubt after missing the Brentford win with a knock, while late fitness calls will be made on Josko Gvardiol and Rodri, who has been sidelined with a groin issue. Nathan Ake could continue alongside Marc Guehi in defense if needed, and Rodri’s absence may force Tijjani Reijnders or Nico Gonzalez into midfield once again.

For Crystal Palace, Eddie Nketiah, Borna Sosa, and Cheick Doucoure are all still unavailable through injury, although Evann Guessand could return after training following a knee problem.

Manchester City vs Crystal Palace Picks

When these two clubs lock horns, there’s typically a lot of goals. Five of the last six meetings have cashed the Over. Instead of an outright winner, I’ll take the Over with confidence.

Pick: Over 2.5 goals (-125)/TonyBet

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Quinn Allen is a sports writer from Vancouver, Canada. His expertise spans across many sports, but he tends to write mostly European soccer betting previews for BettingTop10 Canada. He’s been in the industry for seven years. Quinn loves to be active in his free time, whether it’s working out, walking, or playing soccer.