NFL Week 18 Late Sunday 4PM Slate Best Bets & Betting Odds

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Generally our late Sunday card consists of two, three, or maybe sometimes even four games in the 4PM to 4:25PM window. In Week 18, we have seven. So that means instead of providing you with a best bet for each matchup, we’re going to switch it up this week.
We’ve selected our three favorite picks from across this jumbo seven-game slate and broken them down below. Read on for our Week 18 best bets as well as the top NFL betting odds in Canada!
2025 Sunday 4PM West Coast Best Bets: 20-13 (+1.65)
Note: None of our best bets feature odds shorter than -200.
Highlights
- There have been 50+ points in 8 of Arizona’s last 11 games
- The Washington Commanders have the worst run defense in the NFL over the last month
- D’Andre Swift has rushed for 50+ yards in 3 straight contests
NFL Week 18 Late Sunday 4PM Betting Picks & Odds - January 4
All odds provided by Bodog.
Arizona Cardinals (3-13) @ Los Angeles Rams (11-5) - 4:25PM
| Team | Moneyline | Point Spread | Total (Over/Under) |
| Arizona Cardinals | +610 | +13.5 (-110) | O47.5 (-110) |
| Los Angeles Rams | -900 | -13.5 (-110) | U47.5 (-110) |
The Los Angeles Rams had one of their ugliest performances of the season in Week 17. They might have even rested some guys in Week 18 had they won. But they didn’t, and head coach Sean McVay was not happy about it. He said adamantly that everyone is going to play in the final regular season game.
And if everyone plays for the Rams, that means they’re going to put up a lot of points. Especially against this subpar Cardinals defense: Arizona has allowed 37+ points in five of their last eight games. And with Jacoby Brissett at the controls, they can always move the ball. The Rams might win this in a blowout, but a 13-point spread is way too susceptible to a backdoor cover. The over feels safer here.
Best Bet: Game Total Points Over 47.5 (-110)
Washington Commanders (4-12) @ Philadelphia Eagles (11-5) - 4:25PM
| Team | Moneyline | Point Spread | Total (Over/Under) |
| Washington Commanders | +180 | +4.5 (-110) | O39.5 (-110) |
| Philadelphia Eagles | -215 | -4.5 (-110) | U39.5 (-110) |
Despite being able to clinch the No. 2 seed and move up from No. 3 in Week 18, the Eagles are going to be resting a lot of starters. I guess they have some championship DNA that says it doesn’t matter if they have homefield advantage in the playoffs or not. Go figure.
With that being said, the Commanders are awful. They have allowed more rushing yards than any other team in the NFL over the last month (726) and with Saquon Barkley likely resting for most if not all of this game, backup Tank Bigsby could have a field day. His rushing yards prop is not yet available, but we like that one just as much as his anytime scorer odds as long as it stays below 50 yards.
Best Bet: Tank Bigsby Anytime Touchdown Scorer (+125)
Detroit Lions (8-8) @ Chicago Bears (11-5) - 4:25PM
| Team | Moneyline | Point Spread | Total (Over/Under) |
| Detroit Lions | +160 | +3.5 (-110) | O50.5 (-110) |
| Chicago Bears | -190 | -3.5 (-110) | U50.5 (-110) |
The Bears have been running the ball really well of late. And while the credit for that should go to both D’Andre Swift and Kyle Monangai, it’s the former who remains the head honcho of this backfield. Swift has rushed for 50+ in each of his last three games.
He now gets a chance to go against a Lions run defense that has given up 638 rush yards over the last month, fourth-most in football. Swift had 63 yards and a score on 12 carries in the first matchup with Detroit earlier this season. And let’s not forget: Swift was drafted by and given up on by this Lions franchise a few years ago. He likes this matchup.
Best Bet: D’Andre Swift To Record 50+ Rushing Yards (-178)
T&Cs Apply
Alex Murray has been a consistent presence on BettingTop10 since he joined the team in 2020 just after graduating from Ryerson University’s Sport Media program in 2019. He has written for publications including theScore, Sporting News, FanSided, FantasyPros, and more over his 6+ years in the field. Alex has also been a lifelong athlete and sports fan who has channeled that love into his entertaining writing style and shrewd betting strategies.

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