2025 NFL Hall of Fame Game Predictions: Detroit Lions vs. L.A. Chargers

Alex Murray
By: Alex Murray
Jul 28, 2025
NFL Picks
Photo by Wikimedia Commons, CC by 2.0

Photo by Wikimedia Commons, CC by 2.0

The NFL’s Hall of Fame Game serves to ring in the new season every year. And while it’s not exactly an entree, it’s a nice appetizer. Both for the Hall of Fame inductions that weekend as well as for the rest of the preseason. We have waited half a year for another semi-competitive game, which means we’re going to be paying attention to this one.

It’s going to be two of the most exciting outfits going into the 2025 NFL season—the Detroit Lions and the Los Angeles Chargers—playing in Canton, though they won’t seem like it. It is preseason after all. But it’s also football, and those backups are fighting for their jobs. So let’s take a look at the limited NFL betting markets we have for this matchup, which promises to be both exciting and boring in equal measure.

Highlights

  • Both head coaches are 1-3 in Week 1 of the preseason in their careers
  • The Chargers are 0-1-1 in the HOF Game, the Lions are 1-2
  • 12 of the last 16 HOF Games have gone under the betting total

2025 NFL Hall of Fame Game: Detroit Lions vs. Los Angeles Chargers Odds & Predictions - July 31

All odds provided by Betway.

Detroit Lions vs. Los Angeles Chargers Odds

TeamMoneylinePoint SpreadOver/Under
Detroit Lions-110-1.0 (-105)O33.0 (-110)
Los Angeles Chargers-110+1.0 (-115)U33.0 (-110)

Lions vs. Chargers Point Spread/Moneyline Prediction

The NFL certainly chose a fun matchup here with one of the most exciting teams in the league in the Lions going up against an up-and-coming (and quite intriguing) Chargers team that plays in the second-biggest market in the league. However, Hall of Fame weekend is more about the pageantry and the Hall of Fame inductees than the actual Game.

This is the preseason game where you’re likely to see the fewest snaps from the players you know. Justin Herbert and Jared Goff might not even play, and if they do, it will be for no more than one series. There’s no way to know enough about the deep dark depths of these teams’ depth charts we’re going to see on Thursday. So this is all about two things: backup QBs and head coaches.

From a coaching perspective, Jim Harbaugh and Dan Campbell share a lot of similarities. Beloved by their charges, able to find early success wherever they go, and oozing passion. However, Campbell saves most of that for the regular season, as he is just 3-6-1 in the preseason in his career, including a 1-3 mark in Week 1.

Harbaugh, meanwhile, is also 1-3 in Week 1 of the preseason, but his teams would get better as the month-long mini-season wore on, putting up a 10-6 preseason record with the 49ers and last year in L.A. Advantage Chargers.

In the backup quarterback department, the Chargers have Taylor Heinicke behind Justin Herbert. That dude is a gamer and a fiery competitor who will undoubtedly be trying to hold Trey Lance off for that backup job. Let’s not forget, Heinicke started 15 games back in 2021 and has started another 14 games since then.

Meanwhile, the Lions will trot out Hendon Hooker (nine career pass attempts) and/or Kyle Allen (one pass attempt in the last two years). Hooker is intriguing despite the lack of playing time as a rookie, we’ll admit. But once again, advantage Chargers.

Prediction: Los Angeles Chargers Moneyline (-110)

Lions vs. Chargers Over/Under Prediction

We like the Chargers a lot—though we might actually wait until closer to kickoff to make that moneyline bet and see if we can get plus odds from Ontario sportsbooks, because the public will love the Lions—but we like the under here even more. As we said, this weekend is more about the players being honored with inductions into the Pro Football Hall of Fame rather than the HOF Game itself.

Because of that, we generally don’t get the best quality football. And when that’s the case, it’s usually the defenses getting the better of it. 12 of the last 16 Hall of Fame Games have gone under their total, including nine that went under this game’s total of 33.0.

Prediction: Game Total Points Under 33.0 (-110)/Betway

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Alex is a recent graduate of Ryerson's Sport Media program in 2019 and has been contributing to BettingTop10 since 2020. He has worked in the field of sports and sports betting for several years, including writing for theScore and daily fantasy sports website FantasyPros as one of their lead NBA news writers. A dedicated sports fan and experienced sports bettor, Alex has the knowledge to provide you with the best betting advice and the sneakiest props no matter what the sport may be.