49ers vs. Seahawks NFL Saturday Odds, Analysis, & Best Bets

Alex Murray
By: Alex Murray
NFL Picks
Public Domain

Public Domain

There are still three NFL division crowns up for grabs in Week 18. Two of those are likely to be decided during the league’s cheeky Saturday doubleheader.

The second of those could very well be the best game of the weekend: the Seattle Seahawks (13-3) head to the Bay to take on the San Francisco 49ers (12-4) in a matchup that will decide the winner of the stacked NFC West, which already had three 11-win teams. Read on as we break down this contest and reveal our best bets and favorite player props for the action.

Highlights

  • The 49ers have the 2nd-best over record in the NFL at 10-5-1
  • San Francisco has won 7 of 8 meetings between these teams since 2022
  • George Kittle has recorded 65+ yards in 6 straight games

NFL Saturday Week 18 - San Francisco 49ers vs. Seattle Seahawks Odds & Picks - Jan. 3 (8PM)

All odds provided by Betway.

TeamMoneylinePoint SpreadOver/Under
San Francisco 49ers+116+2.5 (-110)O47.5 (-115)
Seattle Seahawks-136-2.5 (-110)U47.5 (-105)

49ers vs. Seahawks Game Prediction

In a unique quirk of the schedule these two division rivals will have played their two matchups this season as far apart as possible: in Weeks 1 and 18. For that reason, we don’t believe it’s overly useful to look at that first matchup for trends that could help us for this matchup nearly four months later.

Both teams come into this one having won six straight, but the real question here is whether or not Brock Purdy and company can put up the numbers they have been doing recently against this stingiest of Seahawks defenses. Because we know the Seahawks are going to be able to move it on this injury-plagued 49ers defense.

Since this one is so tight, we’re going to go with the 49ers as they are not only getting points here, but they’re getting them at home. We’ll also buy up a point to get it above that pesky 3-point threshold betting apps always like to mess around with.

On top of that, we’re also looking at the total for this one. Only the Cowboys have a better record hitting overs this year than the 49ers, who have gone 10-5-1 on the over. And even with that tough defense, Seattle has hit six overs in their last 10 games.

The 49ers have allowed 37+ points in three straight games as their offensive playmakers have all returned to full health. But their missing defensive stars are gone for good, and they have allowed 24+ points in each of those games as well. We smell an over here. 
 
Best Bets

  • Game Total Points Over 47.5 (-110)
  • San Francisco 49ers Alternative +3.5 Point Spread (-155)

49ers vs. Seahawks Player Prop Best Bet

The Seahawks aren’t susceptible to much defensively. But they have been known to give it up to a tight end from time to time. They allow 65.7 yards per game to TEs, fifth-most in the NFL. That includes some big games for TEs from the Rams, Falcons, and Vikings in recent weeks.

And none of those guys are nearly on the level of a George Kittle. The man missed six games and still made the Pro Bowl. And if he’d played a couple of more, he probably would have been an All-Pro too. Kittle picked up a hamstring injury in September and struggled in his first three games after returning in October, amassing just 75 yards across those contests.

However, he’s been on a bonafide heater since then, posting 5+ targets, 4+ receptions, and 67+ receiving yards in each of the six games since then. That’s an average of over 83 yards per game over the last month and a half. He missed last week with an ankle issue, but Kittle said he’s feeling “fabulous” and said he “absolutely” expects to play in Week 18.

Dial him up.

Best Bet: George Kittle To Record 60+ Receiving Yards (-125)

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Alex Murray has been a consistent presence on BettingTop10 since he joined the team in 2020 just after graduating from Ryerson University’s Sport Media program in 2019. He has written for publications including theScore, Sporting News, FanSided, FantasyPros, and more over his 6+ years in the field. Alex has also been a lifelong athlete and sports fan who has channeled that love into his entertaining writing style and shrewd betting strategies.