Giants vs. Eagles Week 6 TNF: NFL Betting Odds & Picks

Alex Murray
By: Alex Murray
Oct 09, 2025
NFL Picks
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Once again, Amazon Prime’s Thursday Night Football crew gets a divisional matchup. The Philadelphia Eagles and the New York Giants have one of the great football rivalries of all-time. But it’s been a bit one-sided recently.

The Eagles have won six of the last seven and head to MetLife Stadium with a 4-1 record to take on a 1-4 Giants team that has a very different feeling around it now than it did just one week ago. Check out the top betting odds as well as our predictions for the prime time matchup in East Rutherford, New Jersey.

2025 TNF Best Bets Record: 9-8 (-1.52)

Note: None of our best bets feature odds shorter than (-200).

Highlights

  • Philly has covered the point spread in six of their last eight divisional games
  • The under is 8-3 when the Giants are at home since the start of 2024
  • The Giants have allowed 5 rushing TDs to opposing RBs this season (5th-most)

NFL Week 6 TNF: New York Giants vs. Philadelphia Eagles Betting Odds & Picks - Oct. 9

All odds provided by Sports Interaction.

TeamMoneylinePoint SpreadOver/Under
New York Giants+310+7.5 (-110)O40.5 (-110)
Philadelphia Eagles-390-7.5 (-110)U40.5 (-110)

Giants vs. Eagles Point Spread/Moneyline Prediction

After blowing a big second-half lead against the Broncos last week to lose their first game of the season, the Eagles will have been looking for a “get right” game. And they are blessed with one here just four days later. Now, this is still a divisional game, which means there’s always worry for the favorite. But the Giants don’t instill very much worry in us right now.

The Giants are not looking nearly as frisky as they were a week ago. We admit, we are loath to even wager on a game involving the Giants at all considering how they’ve boned us the last two weeks. But they’re in prime time, so there is no choice.

And it does make us feel a bit safer to know that New York has been awful as a betting underdog since the start of 2024, putting up an ugly 7-14 ATS mark, eighth-worst in the league. They’re also 4-7 ATS as a home underdog over that span.

Philly, meanwhile, has covered the spread in six of their last eight divisional games, and their 5-2 ATS mark as a road favorite dating back to 2024 is tied for fourth-best in the NFL. They’ve also won six of eight against Big Blue since 2022. We’ll buy the spread down below a TD, but we love the Birds in this spot.

Prediction: Philadelphia Eagles Alternative -6.5 Point Spread (-140)

Giants vs. Eagles Over/Under Total Prediction

With the number way down at 40.5, we really wanted to take the over here. But we simply couldn’t do it. The Giants offense looks like a complete mess when they’re not executing fully laid out plans for their first or second drives of games. The Eagles offense is also lacking in identity.

The only worry here is that the Giants defense is so bad that Philly scores over 40 on their own. They did give up 26 to Spencer Rattler and company, but we don’t see a 40-burger being dropped by anyone on a short week in a divisional game.

The under has also been very popular at MetLife Stadium. Since the start of 2024, the under is 8-3 at Giants home games, and both New York and Philly have seen five of their last eight divisional games go under the total as well.

Prediction: Alternative Game Total Points Under 42.5 (-138)

Giants vs. Eagles Player Prop Best Bets

PlayerAnytime Touchdown Odds
Saquon Barkley, RB (PHI)-165
Jalen Hurts, QB (PHI)-130
Cam Skattebo, RB (NYG)+155
A.J. Brown, WR (PHI)+190
Dallas Goedert, TE (PHI)+250
DeVonta Smith, WR (PHI)+250
Tyrone Tracy Jr., RB (NYG)+360
Jaxson Dart, QB (NYG)+360
Wan’Dale Robinson, WR (NYG)+360

Who else could it be but Saquon Barkley. He had one of the most acrimonious player-team divorces in recent memory when he left the Giants for the Eagles last year. And unsurprisingly, he made Big Blue pay for not paying him: he put up 176 yards and a score against New York in his return to MetLife last season.

And the Giants, thankfully for him, still have a pretty bad run defense despite a lot of big names in their front seven. New York has allowed 533 rushing yards to running backs this season, eighth-most in the NFL. The five rushing TDs they’ve allowed to RBs is tied for fifth-most as well. The 5.3 yards per carry they’re giving up is fourth-most in football.

Barkley has not had a very strong start to the season, only topping 80 rushing yards once and failing to reach 100+ scrimmage yards in a game yet. But he’s going to get going, and we believe this will be the week. No doubt Nick Sirianni will want Barkley to at least find pay dirt against his old team. Three RBs have rushed for 80+ against this defense already this season.

Best Bet:

  • Saquon Barkley Anytime Touchdown (-165)
  • Saquon Barkley To Record 100+ Scrimmage Yards (-158)
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Alex is a recent graduate of Ryerson's Sport Media program in 2019 and has been contributing to BettingTop10 since 2020. He has worked in the field of sports and sports betting for several years, including writing for theScore and daily fantasy sports website FantasyPros as one of their lead NBA news writers. A dedicated sports fan and experienced sports bettor, Alex has the knowledge to provide you with the best betting advice and the sneakiest props no matter what the sport may be.