Odds courtesy of TonyBet.
Liverpool vs Atletico Madrid Odds
The Reds are a -137 home moneyline favorite at soccer betting sites. Atletico, meanwhile, is priced as a +370 road underdog. A draw sits at +300 odds.
These two have met frequently in Europe’s most prized competition. Last season, they locked horns in the league phase, with Liverpool running out 3-2 winners at Anfield. Across seven meetings in Europe, the Premier League giants have the edge with three victories, while Atleti have two. The other two fixtures ended level.
Liverpool vs Atletico Madrid Analysis
After nearly missing out on Champions League qualification in 2025-26, the Merseysiders were fortunate that England was given five spots in the competition, securing their involvement this season. Liverpool’s European dreams fell short last year, though, bowing out in the quarterfinals against eventual winner PSG, for the second consecutive season. It was pure domination as well, with the French club beating the Reds 4-0 on aggregate across two legs.
Now, with a new manager in Andoni Iraola, Liverpool will look to return to the knockout stages and hopefully make a deep run. The Reds finally got a win under their belt over the weekend, with Alexander Isak’s brace making the difference against Ipswich Town. To be honest, Liverpool has also been handed a manageable league-phase schedule. Atleti may be their most difficult fixture outside of a meeting with Inter Milan early next year. The hosts have also won two straight games against the Spanish giants at Anfield.
Atletico may rarely be in the mix for the LaLiga title, but they always find a way to compete at a high level in Europe. Diego Simeone’s men were on the verge of the Champions League showpiece last season, losing 2-1 on aggregate to Arsenal in the semifinals. However, this side hasn’t looked great so far domestically, and they’re fresh off a disappointing 3-0 defeat to Athletic Club on the weekend.
Now, with just two days’ rest in between, Atleti must travel across Europe to Liverpool for a tough clash against a side that is historically better on home turf. The LaLiga side also has a tougher group-stage schedule than the Reds. Aside from facing one of the strongest teams on the continent on Wednesday, Atletico also lock horns with Manchester United and Bayern Munich. Regardless, the visitors should be feeling some confidence heading into matchday one after their best UCL campaign in nearly a decade.
Liverpool vs Atletico Madrid Injury News
Liverpool will be without Hugo Ekitike (Achilles), Conor Bradley (knee) and Giovanni Leoni (ACL) for Wednesday’s Champions League clash, while Joe Gomez remains doubtful with a muscle injury. Federico Chiesa and Wataru Endo are also unavailable after being left out of Liverpool’s Champions League squad.
Atlético Madrid have a much shorter injury list, with Alexander Sørloth set to miss the trip to Anfield due to a muscle problem that has sidelined him since before the start of the La Liga season. Julián Álvarez is available after recently recovering from illness and took part in training on Monday, while Arnau Ortiz will miss the match through suspension.
Liverpool vs Atletico Madrid Picks
The Reds were impressive a few days ago against Ipswich, and their attack is firing on all cylinders. I expect the likes of Isak and Cody Gakpo to create issues for an Atletico backline that just conceded three to Bilbao. I’ll take Liverpool at -137.
Pick: Liverpool -137 /TonyBet
