We would have nailed our first six-leg, six-point teaser of the 2025 NFL season in Week 1. We just didn’t know the Miami Dolphins were going to decide to call in sick in Indianapolis. Otherwise, we were right on. We’ll look to avoid such a fatal flaw in our teaser parlay for Week 2’s action. Check out our picks below!
NFL Pick 6: Week 2 6-Leg, 6-Point Teaser Parlay

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Highlights
- The Lions and Bills straight up is a strong foundation for the parlay
- Kansas City has too many injury issues to take revenge on the Eagles
- We like the Bucs to win on MNF, so getting them at a near double-digit spread was a treat
NFL Pick 6: Week 1 6-Leg, 6-Point Teaser Parlay
All odds provided by Sports Interaction.
- (A) Los Angeles Rams -5.5 Spread → +0.5
- (H) Detroit Lions -6.5 Spread → -0.5
- (A) Buffalo Bills -6.5 Spread → -0.5
- (A) San Francisco 49ers -3.0 Spread → +3.0
- (A) Philadelphia Eagles -1.5 Spread → +4.5
- (A) Tampa Bay Buccaneers +2.5 Spread → +8.5
- Parlay Odds: +600
Los Angeles Rams (-5.5) @ Tennessee Titans - 1PM
Tennessee’s head coach doesn’t know what constitutes a catch in today’s NFL, and Cam Ward’s offensive line can’t do their jobs. Six sacks in your debut is tough. The Rams have their own offensive line injuries to deal with, but Stafford’s back should hold up for at least one more week.
Teaser Pick: Rams +0.5
Chicago Bears @ Detroit Lions (-6.5) - 1PM
In our only home pick of the week, we like the Lions to bounce back after a humbling experience against the Packers in Week 1. The Vikings were able to find success running the ball with Jordan Mason last week, so we expect Detroit to run the ball down Chicago’s throat and get a comfortable win to send Ben Johnson to a surprising 0-2 record to start his ballyhooed tenure in the Windy City.
Teaser Pick: Lions -0.5
Buffalo Bills (-6.5) @ New York Jets - 1PM
Buffalo’s defense looks like it’s going to need some serious help. But then again, this Jets defense just gave up 30+ points to a 41-year-old Aaron Rodgers. What do we think the reigning NFL MVP is going to do to this sorry lot? Even on the road, the Bills moneyline was too good to turn ignore here.
Teaser Pick: Bills -0.5
San Francisco 49ers (-3.0) @ New Orleans Saints - 1PM
No Brock Purdy has not steered us away from this pick. Mac Jones isn’t exactly inspiring confidence, but if this team can hold onto the ball and run it, they should win comfortably against the Saints, who were actually slightly better than expected in a seven-point loss in Week 1. Even if worst comes to worst, we can’t imagine a world where the 49ers lose by more than a field goal.
Teaser Pick: 49ers +3.0
Philadelphia Eagles (-1.5) @ Kansas City Chiefs - 4:25PM
The Chiefs are underdogs at home, which should tell you everything you need to know about how betting apps are viewing the 2024 NFL runners-up after their disappointing Week 1 loss. They’ve got too many injury issues to deal with to dominate Philly. Even if the Eagles lose, it won’t be by more than a field goal.
Teaser Pick: Eagles +4.5
Tampa Bay Buccaneers @ Houston Texans (-2.5) - 7PM (MNF)
The Buccaneers were able to pull out a late win over the Falcons, which would have been a lot more comfortable had their kicker hit all his extra points. Houston’s offense, by contrast, looked toothless in a 14-9 loss in Week 1. Houston is at home, but we still would have made the Bucs the favorites. We don’t make those calls though, so we’ll gladly add six points to Tampa’s underdog spread here.
Teaser Pick: Buccaneers +8.5
T&Cs Apply
Alex Murray has been a consistent presence on BettingTop10 since he joined the team in 2020 just after graduating from Ryerson University’s Sport Media program in 2019. He has written for publications including theScore, Sporting News, FanSided, FantasyPros, and more over his 6+ years in the field. Alex has also been a lifelong athlete and sports fan who has channeled that love into his entertaining writing style and shrewd betting strategies.

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