NFL Week 11 Late Sunday 4PM Betting Picks & Odds

Alex Murray
By: Alex Murray
NFL Picks
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We’re not sure what it is about that late slate of NFL games at 4PM Eastern Time on Sunday, but we simply love it. We’re on a certified heater since we returned to doing best bets on those late games, having nailed two straight cards (six best bets in a row).

We’ll look to make it lucky number three here in Week 11. Though we’ll have to do it with a slightly bigger slate, as the 4PM schedule features four games this week. Check out our best bet for each one, as well as the top NFL betting odds this side of the border!

2025 Sunday 4PM West Coast Best Bets: 9-1 (+5.94)
Note: None of our best bets feature odds shorter than -200.

Highlights

  • The Cardinals have allowed an opposing TE to go for 50+ yards in 3 of their last 4
  • Jaxon Smith-Njigba has reached the 90-yard plateau in 8 of 9 games this year
  • Cleveland has lost by 7+ points in 6 of their last 8 contests

NFL Week 11 Late Sunday 4PM Betting Picks & Odds - November 16

All odds provided by Sports Interaction.

San Francisco 49ers (6-4) @ Arizona Cardinals (3-6) - 4:05PM

TeamMoneylinePoint SpreadTotal (Over/Under)
San Francisco 49ers-190-3.5 (+100)O48.5 (-110)
Arizona Cardinals+155+3.5 (-120)U48.5 (-110)

George Kittle missed about a month and a half with a hamstring injury, and in his first couple of games back he was rather quiet. But not so last week, when he had a season-high nine targets and went for 84 yards and a TD. Wideout Ricky Pearsall is finally back this week, but that’s likely to affect Jauan Jennings more than Kittle.
 
The big tight end has gone for 50+ yards in eight of his last 12 against the division-rival Cardinals. And for their part, Arizona has allowed 61.1 yards per game to TEs this season. Considering Kittle plays 90 percent of the snaps most games, we like him to get the lion’s share of that and cover the over here.

Best Bet: George Kittle To Record 50+ Receiving Yards (-130)

Seattle Seahawks (7-2) @ Los Angeles Rams (7-2) - 4:05PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Seattle Seahawks+150+3.5 (-125)O49.5 (-110)
Los Angeles Rams-180-3.5 (+100)U49.5 (-110)

Apart from Josh Jacobs and Jonathan Taylor, there is perhaps no more consistent performer in the NFL right now than Jaxon Smith-Njigba. He leads the NFL with 1,041 receiving yards on the year and he has six 100-yard games out of 10, and he’s hit that milestone in three of the last four.

Even better, JSN has hit the 90-yard mark in eight of nine games this year, and we like him to hit that again this week even against the Rams’ tough defense. L.A. has actually allowed over 156 yards per game to WRs this season, 10th-most in football. Either way, JSN has already proven he can perform against top opposition: he went for 123 yards against the Texans, who have the fourth-best pass defense in the league.

Best Bet: Jaxon Smith-Njigba To Record 90+ Receiving Yards (-165)

Baltimore Ravens (4-5) @ Cleveland Browns (2-7) - 4:25PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Baltimore Ravens-450-8.5 (-110)O38.5 (-110)
Cleveland Browns+350+8.5 (-110)U38.5 (-110)

These two teams are on opposite sides of the momentum spectrum right now. The Ravens have won three straight and are right back in the mix for the AFC North title thanks to the return of Lamar Jackson. Cleveland, meanwhile, has lost five of their last six, including an ugly 27-20 defeat at the hands of the previously one-win Jets last week.

Five of Cleveland’s last six losses have come by 7+ points, and all four of Baltimore’s wins this season have come by a touchdown or more. Jackson is also 8-3 against the Browns going back to the tail end of the 2019 campaign.

Best Bet: Baltimore Ravens Alternative -6.5 Point Spread (-140)

Kansas City Chiefs (5-4) @ Denver Broncos (8-2) - 4:25PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Kansas City Chiefs-225-4.5 (-110)O44.5 (-110)
Denver Broncos+185-4.5 (-110)U44.5 (-110)

The Chargers showed a rare weakness in K.C.’s top 10 defense earlier this year: scramblers. Justin Herbert went for 32 in a Week 1 win over the Chiefs. The Chiefs have generally struggled to contain mobile QBs, with Russell Wilson, Lamar Jackson, Trevor Lawrence, and Marcus Mariota all going for 20+ against this Chiefs team. They also allow 26.0 rushing yards per game to QBs, which is fourth-most in football.

Denver QB Bo Nix is certainly a mobile quarterback, and he’s a great scrambler as well, rushing for 20.5 a game so far this year and 23.5 for his young career. He’s had negative rush yards in two of his last three, but we think this is the week he gets back in his groove. Nix has had 20+ on the ground in six of 10 games this season, and 11 of his last 15 (including playoffs) going back to December of last year.

Best Bet: Bo Nix To Record 20+ Rush Yards (-165)

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Alex Murray has been a consistent presence on BettingTop10 since he joined the team in 2020 just after graduating from Ryerson University’s Sport Media program in 2019. He has written for publications including theScore, Sporting News, FanSided, FantasyPros, and more over his 6+ years in the field. Alex has also been a lifelong athlete and sports fan who has channeled that love into his entertaining writing style and shrewd betting strategies.