NFL Week 16 Late Sunday 4PM Slate Best Bets & Betting Odds

Alex Murray
By: Alex Murray
NFL Picks
Attribution-ShareAlike 2.0 Generic

Attribution-ShareAlike 2.0 Generic

Last week, we went 2-3. But we did it with a few of the worst beats you’ll see. Rico Dowdle and Brian Robinson fell a combined five yards short of their props, and Davante Adams pulled his hammy halfway through his game to thwart us.

After our first negative card of the season, we’re dying to get back on the horse and bounce back in a big way with a four-game slate here in Week 16. Read on for the top betting odds you’ll find at Ontario sportsbooks as well as our best bet for each game in the late 4PM window on Sunday.

2025 Sunday 4PM West Coast Best Bets: 20-9 (+5.65)

Note: None of our best bets feature odds shorter than -200.

Highlights

  • The Broncos are the only undefeated team at home this season, with a 7-0 record
  • Jacoby Brissett had 249 passing yards against the best defense in the NFL last week
  • Jahmyr Gibbs is averaging 96.6 rush yards per game at home, 4th-best in the NFL

NFL Week 16 Late Sunday 4PM Betting Picks & Odds - December 21

All odds provided by Bodog.

Jacksonville Jaguars (10-4) @ Denver Broncos (12-2) - 4:05PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Jacksonville Jaguars+150+3.5 (-120)O46.5 (-120)
Denver Broncos-178-3.5 (-102)U46.5 (-102)

The Jacksonville Jaguars have been on a roll lately, winning their last five in a row to take control of the AFC South. However, we’re not sure about the quality of opponent they’ve beaten during that run. And the Denver Broncos haven’t lost since September 21.

Denver has also beaten three quality playoff opponents as well as the competitive Cowboys and Chiefs during that run. They are the only team that is undefeated at home, sporting a 7-0 record at Mile High this season. Trevor Lawrence rarely has two great games in a row, and we think the Broncos’ top-rated pass rush will give him fits. The home winning streak won’t end here.

Best Bet: Denver Broncos Moneyline (-178)

Atlanta Falcons (5-9) @ Arizona Cardinals (3-11) - 4:05PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Atlanta Falcons-154-2.5 (-120)O48.5 (-105)
Arizona Cardinals+130+2.5 (-102)U48.5 (-115)

Jacoby Brissett is simply a machine. He has come into this Arizona Cardinals offense and found a way to move the ball every single week. He has not thrown for fewer than 249 yards in any of his nine starts. Brissett threw for 249 yards against the best defense in the league last week against the Texans. That means he should have no problem continuing to pile up the yardage here against a middle-of-the-road Falcons pass defense.

Best Bet: Jacoby Brissett To Record 250+ Passing Yards (-132)

Pittsburgh Steelers (8-6) @ Detroit Lions (8-6) - 4:25PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Pittsburgh Steelers+265+6.5 (-102)O51.5 (-115)
Detroit Lions-330-6.5 (-120)U51.5 (-105)

Since the Pittsburgh Steelers’ first-round rookie defensive tackle Derrick Harmon was injured a few weeks ago, the run defense has struggled. They gave up 200 yards in back-to-back weeks before seemingly tightening up on MNF last week. But even still, De’Von Achane had 60 yards on just 12 carries. Pittsburgh has allowed 628 yards on the ground over the last four weeks, second-most in football.

Meanwhile, Jahmyr Gibbs has been the definition of dominant at home this season. He is averaging 96.6 rushing yards per game at home (fourth-most) compared to 60.6 on the road. Gibbs has also had three straight subpar rushing games, which means he’s due for an explosion. And with T.J. Watt also likely out for Pittsburgh, Ford Field looks like a tinder box for Gibbs on Sunday.

Best Bet: Jahmyr Gibbs Over 75.5 Rushing Yards (-110)

Las Vegas Raiders (2-12) @ Houston Texans (9-5) - 4:25PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Las Vegas Raiders+750+14.5 (-120)O37.5 (-120)
Houston Texans-1,200-14.5 (+100)U37.5 (-102)

Usually a double-digit spread is something you don’t want to go near, but this Las Vegas Raiders team is making us consider it. Not only are they on the road, but they’ve been pretty bad as underdogs this season. They’ve gone 3-7 ATS in their last 10 games as underdogs.

But that’s not even really the worrying thing. In three games where they’ve been underdogs of 10+ points this season, they are 0-3—against the spread. That is pitiful. And they have lost those games by an average of 20.7 games. Woeful. Houston is on a roll, they’re at home, and this Raiders team is surely in tank mode at this point.

Best Bet: Houston Texans Alternative -13.5 Point Spread (-120)

bodog
$400 Welcome Bonus + 50 Free Spins
$400 Welcome Bonus + 50 Free Spins

T&Cs Apply

Alex Murray has been a consistent presence on BettingTop10 since he joined the team in 2020 just after graduating from Ryerson University’s Sport Media program in 2019. He has written for publications including theScore, Sporting News, FanSided, FantasyPros, and more over his 6+ years in the field. Alex has also been a lifelong athlete and sports fan who has channeled that love into his entertaining writing style and shrewd betting strategies.