NFL Week 2 Early 1PM Slate Betting Picks, Odds, & Best Bets

We can do all the research we want before the season, but things can turn out completely differently once the ball is actually snapped in regular season play. We will look to bounce back from an ugly Week 1 performance with this mega nine-game slate coming up for us in the early 1PM window this Sunday in Week 2.

2025 1PM Slate Best Bet Record: 3-5 (-2.79)

Note: None of our best bets feature odds shorter than -200.

NFL Week 2 Early Sunday 1PM Betting Picks & Odds - September 14

All odds provided by Sports Interaction.

Cleveland Browns @ Baltimore Ravens - 1PM

Despite all the talk about how the Ravens are chokers over the past week, that Buffalo game was only the third time since 2019 that they’ve lost a game after entering the 4th quarter with a two TD lead. Actually, that doesn’t sound great, does it. But still, the other two times it happened, they came back and won big by 11 and 14 the next week. They’ll do it again here and cover the spread.

Best Bet: Baltimore Ravens -11.5 Point Spread (-110)

Los Angeles Rams @ Tennessee Titans - 1PM

The Titans seem like they’ve got a lot to figure out when it comes to their coaching staff and their offensive line, which gave up six sacks last week as Cam Ward was unable to even register one rushing attempt. The Rams will win this, though their own injury issues along the offensive line make us want to buy a couple points from NFL sportsbooks on their -5.5 spread.

Best Bet: Los Angeles Rams Alternative -3.5 Point Spread (-154)

Chicago Bears @ Detroit Lions - 1PM

We think the Lions are going to get back to their roots and run the ball here; Jordan Mason had 68 yards on 15 carries last week. Meanwhile, Lions RB Jahmyr Gibbs had just 19 yards in his season debut. In the other six games where Gibbs had 40 yards or fewer in his career, he averaged 78.2 yards, topping 68 yards in five of those.

Best Bet: Jahmyr Gibbs To Rush For 60+ Yards (-180)

Buffalo Bills @ New York Jets - 1PM

The respective defensive units for these teams did not make a good account of themselves last week against AFC North competition. However, that has led Vegas to boost this division battle’s over/under higher than it should be: only two of the last eight meetings between the Bills and Jets have gone over 50 total points.

Best Bet: Alternative Game Total Points Under 50.5 (-166)

New York Giants @ Dallas Cowboys - 1PM

The Giants defense couldn’t stop the run or pass last week, giving up the 7th-most yards in the NFL to WRs in Week 1. And Dallas’ CeeDee Lamb is primed to bounce back after a drop-filled—yet productive—debut last week. The All-Pro will want to get the sour taste out of his and everyone else’s mouth as quickly as possible.

Best Bet: CeeDee Lamb Over 78.5 Receiving Yards (-110)

San Francisco 49ers @ New Orleans Saints - 1PM

The San Francisco 49ers have somehow brought their 2024 injury curse with them into this 2025 season. Starting QB Brock Purdy is out and so is All-Pro TE George Kittle. But it’s okay, because they lucked out with a matchup against possibly the worst team in football here. We’re not confident enough in Mac Jones to go beyond the moneyline though.

Best Bet: San Francisco 49ers Moneyline (-162)

New England Patriots @ Miami Dolphins - 1PM

We were thinking about going with the under here, as is often a safe bet in divisional matters, but the recent history of this game gave us pause. Nine of the last 12 meetings between these teams in Miami have totaled 43+ points. We’re buying a few and taking the over here. Tyreek Hill can’t keep quiet forever, can he?

Best Bet: Alternative Game Total Points Over 40.5 (-172)

Jacksonville Jaguars @ Cincinnati Bengals - 1PM

The Jaguars don’t have nearly the same level of defensive talent that the Browns do, so we like Cincy here. The Bengals will be revving their engines to get back out there after a somewhat embarrassing showing from the supposedly high-powered offense last Sunday.

Best Bet: Cincinnati Bengals Moneyline (-180)

Seattle Seahawks @ Pittsburgh Steelers - 1PM

Part of the reason Pittsburgh’s defense struggled in Week 1 was losing top cornerback Joey Porter Jr. to a hamstring injury which has ruled him out for this one as well. Time to hop on board the Jaxon Smith-Njigba train. Seattle’s WR1 had nine receptions for 124 yards and an NFL-high 59.1 target share last week.

Best Bet: Jaxon Smith-Njigba 70+ Receiving Yards (-120)