NFL Week 3 Early 1PM Slate Betting Picks, Odds, & Best Bets

Alex Murray
By: Alex Murray
Sep 21, 2025
NFL Picks
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CC0 1.0 Universal

For those that believed, you were rewarded last Sunday afternoon. We had a rough 3-5 start to the season in Week 1, but in Week 2 we nailed each and every one of our nine 1pm early slate picks. Whether you took them straight as singles or parlayed them, those who tailed us won big. Cheers.

We’ll look to stay hot here in Week 3 with another nine-game docket for Sunday’s 1pm slate! Check out our best bets and betting odds below!

2025 1PM Slate Best Bet Record: 12-5 (+3.44)

Note: None of our best bets feature odds shorter than -200.

Highlights

  • Philadelphia beat the Rams twice last year and we believe they will do it again
  • After two tough road wins, the Buccaneers will win big in their home opener
  • Jacksonville is no pushover, but the Texans starting 0-3 feels near impossible

NFL Week 3 Early Sunday 1PM Betting Picks & Odds - September 21

All odds provided by Sports Interaction.

Las Vegas Raiders @ Washington Commanders - 1PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Las Vegas Raiders+130+3.0 (-110)O43.5 (-110)
Washington Commanders-154-3.0 (-110)U43.5 (-110)

Since Jayden Daniels came on as the starting QB for the Commanders, they are 7-2 ATS when they come into a game as the home favorite. The Raiders have looked frisky so far, but with Washington having a few extra days to prepare, we feel comfortable going moneyline here.

Best Bet: Washington Commanders Moneyline (-154)

Atlanta Falcons @ Carolina Panthers - 1PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Atlanta Falcons-225-5.5 (-110)O43.5 (-110)
Carolina Panthers+188+5.5 (-110)U43.5 (-110)

Both of these matchups were barnburners last year, and despite three of the four games these teams have played so far this season going under the total, we think we’ll get another one here. Both offenses seem to be finding their rhythm, and the Panthers’ defense in particular has been poor.

Best Bet: Alternative Game Total Points Over 40.5 (-178)

Green Bay Packers @ Cleveland Browns - 1PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Green Bay Packers-400-7.5 (-110)O41.5 (-110)
Cleveland Browns+315+7.5 (-110)U41.5 (-110)

The fact that this is not a double-digit spread is very surprising. The Packers have looked like the best team in the league, and the Browns have predictably looked like one of the worst. They may be at home, but we have a hard time believing Cleveland keeps this within a score.

Best Bet: Green Bay Packers Alternative -6.5 Point Spread (-136)

Pittsburgh Steelers @ New England Patriots - 1PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Pittsburgh Steelers-126-1.5 (-110)O44.5 (-110)
New England Patriots+108+1.5 (-110)U44.5 (-110)

These are not your father’s Steelers. They can no longer run the ball, and more importantly, they can’t stop the run either. They’ve allowed 249 rushing yards to running backs through two weeks, second-most in football. We like TreVeyon Henderson to continue getting more involved for the Patriots and find success against this swiss cheese run defense of Pittsburgh.

Best Bet: TreVeyon Henderson Over 22.5 Rush Yards (-110)

Los Angeles Rams @ Philadelphia Eagles - 1PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Los Angeles Rams+156+3.5 (-110)O44.5 (-110)
Philadelphia Eagles-186-3.5 (-110)U44.5 (-110)

The Rams were famously pummeled by Saquon Barkley on two occasions last year. And while we believe Los Angeles will be able to lock up the OPOY this time around, the Eagles are too good to lose at home. We’ll play it safe with them and go moneyline here.

Best Bet: Philadelphia Eagles Moneyline (-186)

Indianapolis Colts @ Tennessee Titans - 1PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Indianapolis Colts-235-4.5 (-110)O43.5 (-110)
Tennessee Titans+194+4.5 (-110)U43.5 (-110)

We’re not sure yet whether the Colts are for real, but we do think they are a lot better than this mess of a Titans team. We’d love to get them under three points just to be safe, but the value lies just above that marker, so we’ll go where the value is.

Best Bet: Indianapolis Colts Alternative -3.5 Point Spread (-138)

New York Jets @ Tampa Bay Buccaneers - 1PM

TeamMoneylinePoint SpreadTotal (Over/Under)
New York Jets+250+6.5 (-110)O43.5 (-110)
Tampa Bay Buccaneers-310-6.5 (-110)U43.5 (-110)

Tampa Bay has toughed it out through two difficult road games to start the season. They have emerged 2-0, and now they get the lowly Jets in their home debut. Since Baker Mayfield came on in 2023, the Bucs are 8-3 ATS against AFC opponents, and this isn’t exactly the cream of the crop from that conference either.

Best Bet: Tampa Bay Buccaneers -6.5 Point Spread (-110)

Cincinnati Bengals @ Minnesota Vikings - 1PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Cincinnati Bengals+130+3.0 (-110)O42.5 (-110)
Minnesota Vikings-154-3.0 (-110)U42.5 (-110)

This is one of the toughest matchups to handicap this week. Both teams are playing backup QBs, so smart money would suggest the under right? Well, both of these teams have such good skill position players, we believe this might turn out to be a shootout.

Best Bet: Alternative Game Total Points Over 39.5 (-162)

Houston Texans @ Jacksonville Jaguars - 1PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Houston Texans+110+1.5 (-110)O43.5 (-110)
Jacksonville Jaguars-130-1.5 (-110)U43.5 (-110)

The Texans have somehow started 0-2, and with the Colts coming out of nowhere to start 2-0, they are kind of in desperation mode here at Jacksonville in Week 3. The Jags won’t be as desperate, and they’re not a better team than Houston anyway, so the plus odds on the Texans’ moneyline is welcome.

Best Bet: Houston Texans Moneyline (+110)

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Alex is a recent graduate of Ryerson's Sport Media program in 2019 and has been contributing to BettingTop10 since 2020. He has worked in the field of sports and sports betting for several years, including writing for theScore and daily fantasy sports website FantasyPros as one of their lead NBA news writers. A dedicated sports fan and experienced sports bettor, Alex has the knowledge to provide you with the best betting advice and the sneakiest props no matter what the sport may be.