NFL Week 6 Early 1PM Slate Betting Picks, Odds, & Best Bets

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We have a seven-game slate set for Sunday’s early afternoon schedule at 1PM for Week 6, and there are a lot of intriguing matchups! We’ve got you covered with the top betting odds as well as our best bets for each of the seven games on the docket!
2025 1PM Slate Best Bet Record: 22-17 (-1.58)
Note: None of our best bets feature odds shorter than -200.
Highlights
- Steelers head coach Mike Tomlin is 26-6 straight up against rookie QBs
- Jim Harbaugh is 4-1 straight up after losing two straight games as an NFL head coach
NFL Week 6 Early Sunday 1PM Betting Picks & Odds - October 12
All odds provided by Sports Interaction.
Cleveland Browns @ Pittsburgh Steelers - 1PM
| Team | Moneyline | Point Spread | Total (Over/Under) |
| Cleveland Browns | +225 | +5.5 (-110) | O38.5 (-110) |
| Pittsburgh Steelers | -275 | -5.5 (-110) | U38.5 (-110) |
The Browns have won five of the last 11 meetings between these teams, but it’s worth having a look at the location of those games. When they play in Pittsburgh, the Browns essentially don’t even have a chance. The Browns beat the Steelers in Pittsburgh during the 2020 playoffs. Just in the regular season though? The Browns haven’t won in Pittsburgh since 2003. That’s 21 straight wins, and 15 of those came by double-digits.
Best Bet: Pittsburgh Steelers -5.5 Point Spread (-110)
Los Angeles Chargers @ Miami Dolphins - 1PM
| Team | Moneyline | Point Spread | Total (Over/Under) |
| Los Angeles Chargers | -190 | -4.5 (-110) | O43.5 (-110) |
| Miami Dolphins | +158 | +4.5 (-110) | U43.5 (-110) |
The Los Angeles Chargers were being treated like the next big thing after their 3-0 start. Back-to-back losses to the lowly Giants and the Commanders have people rethinking their bullish opinions of Justin Herbert and company. However, those back-to-back losses make this a must-win for the Chargers in our eyes, and the Dolphins have not proven their ability to hang with quality teams.
Best Bet: Los Angeles Chargers Moneyline (-190)
New England Patriots @ New Orleans Saints - 1PM
| Team | Moneyline | Point Spread | Total (Over/Under) |
| New England Patriots | -184 | -3.5 (-110) | O45.5 (-110) |
| New Orleans Saints | +154 | +3.5 (-110) | U45.5 (-110) |
The Saints just got a big win last week. It was surprising, shocking, jaw-dropping. All of the above. But considering where the Saints are in their long-term plan, there’s no way they’re winning two games in a row this season. That would just throw a wrench in their plans. The Patriots are feeling very good after their upset win over the Bills, and we think they keep it rolling against a team that doesn’t want to win anyway.
Best Bet: New England Patriots Alternative -2.5 Point Spread (-148)
Seattle Seahawks @ Jacksonville Jaguars - 1PM
| Team | Moneyline | Point Spread | Total (Over/Under) |
| Seattle Seahawks | -104 | +1.5 (-110) | O47.5 (-110) |
| Jacksonville Jaguars | -112 | -1.5 (-110) | U47.5 (-110) |
The Jags are coming off an emotional upset victory over the reigning AFC-champion Chiefs this past Monday night. That means that not only are they coming in off a short week, but an emotional one. Seattle just lost a tough one to the Buccaneers as well, and we think that emotional imbalance will give the Seahawks the edge in this one.
Best Bet: Seattle Seahawks Moneyline (-104)
Arizona Cardinals @ Indianapolis Colts - 1PM
| Team | Moneyline | Point Spread | Total (Over/Under) |
| Arizona Cardinals | +310 | +7.5 (-110) | O46.5 (-110) |
| Indianapolis Colts | -390 | -7.5 (-110) | U46.5 (-110) |
The Cardinals just choked away maybe the most clear victory in recent NFL memory last week. Now, they have to head to Indy to take on a Colts offense that is looking like a bit of a juggernaut. The Colts have scored on 75 percent of their drives this season, and the Cardinals on the road don’t seem like the outfit to change that trend.
Best Bet: Indianapolis Colts Alternative -6.5 Point Spread (-130)
Los Angeles Rams @ Baltimore Ravens - 1PM
| Team | Moneyline | Point Spread | Total (Over/Under) |
| Los Angeles Rams | -390 | -7.5 (-110) | O44.5 (-110) |
| Baltimore Ravens | +310 | +7.5 (-110) | U44.5 (-110) |
This spread is assuming Lamar Jackson is not going to play, and so will we. Without Lamar and with the sheer number of injuries on the defensive side of the ball for the Ravens, there’s just no way this one’s a competition, even with the Ravens at home and in dire straits here.
Best Bet: Los Angeles Rams Alternative -6.5 Point Spread (-140)
Dallas Cowboys @ Carolina Panthers - 1PM
| Team | Moneyline | Point Spread | Total (Over/Under) |
| Dallas Cowboys | -172 | -3.0 (-110) | O49.5 (-110) |
| Carolina Panthers | +144 | +3.0 (-110) | U49.5 (-110) |
Apart from what seems like an utterly flukey 30-0 win over the Falcons a few weeks ago, the Panthers have allowed 24+ points to each of their opponents. The Cowboys, meanwhile, have allowed the fourth-most points and the second-most yards so far this year. Three of Dallas’ last four games have seen the total fly way past 50, and we like that trend to continue against another poor defensive unit here.
Best Bet: Game Total Points Over 48.5 (-110)
T&Cs Apply
Alex Murray has been a consistent presence on BettingTop10 since he joined the team in 2020 just after graduating from Ryerson University’s Sport Media program in 2019. He has written for publications including theScore, Sporting News, FanSided, FantasyPros, and more over his 6+ years in the field. Alex has also been a lifelong athlete and sports fan who has channeled that love into his entertaining writing style and shrewd betting strategies.

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