NFL Week 12 Late Sunday 4PM Betting Picks & Odds

With an extra game in the Sunday 4PM late window last week, we weren’t able to keep our perfect run going. However, we still hit 3-of-4 in Week 11, with Bo Nix’s rushing yards prop serving as our one miss. We must remember that no matter how fun they seem, those QB rushing props are simply too fickle.

We get an ugly quartet of games here in Week 12’s late 4PM (EST) window on Sunday, with two at 4:05 and two at 4:25. We’ll look to continue building our bank here with another positive card. Read on for our best bets and analysis as well as the top betting odds from the best Canadian betting apps.

2025 Sunday 4PM West Coast Best Bets: 12-2 (+7.03)

Note: None of our best bets feature odds shorter than -200

NFL Week 12 Late Sunday 4PM Betting Picks & Odds - November 23

All odds provided by Sports Interaction.

Cleveland Browns (2-8) @ Las Vegas Raiders (2-8) - 4:05PM

Call us basic, but we really wanted to get a bet in on Shedeur Sanders for his first career start. We think he showed flashes last week, and he really should have had the game-tying TD toss if not for a drop. Betting sites are saying that Sanders is more likely to throw an INT than a TD, and while we agree with that, the -198 odds on a Sanders INT are not calling to us.

His -154 odds to throw at least one score, however, look a lot more reasonable. Especially when you consider that this Raiders defense has allowed at least one passing TD in all but one game this season. And in that one exception, they still gave up 30 points. Many including Shedeur likely thought the Raiders would draft him as well, so there could be some extra incentive for young Sanders here as well.

Best Bet: Shedeur Sanders To Throw 1+ TDs (-154)

Jacksonville Jaguars (6-4) @ Arizona Cardinals (3-7) - 4:05PM

The Jags allow 69.4 receiving yards per game to tight ends, third-most in the NFL. Apart from last week, they had allowed an opposing TE to hit the over on their receiving yards prop in every single week of the season, including a few performances of 60+ yards over the past five weeks from the likes of Brock Bowers, A.J. Barner, and Travis Kelce.

Trey McBride is arguably the best TE doing it right now. He’s had 70+ in four of five games, including back-to-back games with 100+ yards. As long as Jacoby Brissett is slinging it, McBride should continue putting up monster numbers.

Best Bet: Trey McBride Over 75.5 Receiving Yards (-110)

Atlanta Falcons (3-7) @ New Orleans Saints (2-8) - 4:25PM

Surprisingly, considering the QB matchup, the trends are telling us to go with the over on this one. The Saints have hit six straight unders, but this will be just their second total coming in under 40.

Prior to last week’s 17-7 win over the Panthers, the Saints had had seven of eight games hit the 40-point benchmark. On the Atlanta side, the Falcons had two of their first three games of the season go under this number, but seven of their last eight have gone way over this number. They have allowed 24+ in four straight games and have scored 24+ in five of their last seven.

Best Bet: Game Total Points Over 39.5 (-110) 

Philadelphia Eagles (8-2) @ Dallas Cowboys (4-5-1) - 4:25PM

Jalen Hurts had just 152 passing yards when these teams met in Week 1. Since then, he has had 200+ passing yards in just four of nine games. But with all of A.J. Brown’s comments and three straight weeks with under 200, we believe the Eagles are going to make this a game where they attack through the air.

The Cowboys are beyond susceptible to that anyway. They allow 250 net passing yards per game, third-most in the NFL. The 268.4 pass yards they allow per game to QBs is second-most. They have allowed a QB to throw for 200+ passing yards in eight of 10 games. In the other two: Jayden Daniels and Marcus Mariota combined for over 200, and Bryce Young finished with 199.

Best Bet: Jalen Hurts To Record 200+ Passing Yards (-148)