NFL Week 13 Late Sunday 4PM Slate Betting Picks & Odds

Alex Murray
By: Alex Murray
NFL Picks
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Last week we had another jumbo four-game slate in the late afternoon and that extra game cost us again. We went 3-for-4 for the second straight week. Thanks a lot, Blake Grupe (sorry about your job though).

But that means we still stayed in the black. And with a more manageable three-game slate here in Week 13 in the late afternoon Sunday window, we have our eyes on a perfect betting card this time around. Read on for our best bets and picks, as well as the top NFL betting odds this side of the Canadian border!

2025 Sunday 4PM West Coast Best Bets: 15-3 (+8.27)

Note: None of our best bets feature odds shorter than -200.

Highlights

  • Jaxon Smith-Njigba is averaging over 119 receiving yards per game this season
  • Buffalo is allowing 118.4 rushing yards per game to RBs, 3rd-most in football
  • The Raiders have allowed 11 rushing TDs to RBs this season, tied for 4th-most in the NFL

NFL Week 13 Late Sunday 4PM Betting Picks & Odds - November 30

All odds provided by Sports Interaction.

Minnesota Vikings (4-7) @ Seattle Seahawks (8-3) - 4:05PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Minnesota Vikings+640+11.5 (-105)O41.5 (-110)
Seattle Seahawks-950-11.5 (-115)U41.5 (-110)

Seahawks star wideout Jaxon Smith-Njigba is just having one of those seasons. So why not just hold on and go along for the ride? He has recorded 90+ receiving yards in all but one game this year, including 100+ in six of his last seven games. JSN has proven himself impervious to matchups during this campaign.

He does as much damage against the worst defense in the league as he does a top unit like Houston’s, against whom he had 123 yards a few weeks ago. The Vikings are a pretty good passing defense, but they’re nothing special. There's no reason to think they will be able to handle JSN any better than these other units. As long as this line stays below -200, we’re hammering it every week.

Best Bet: Jaxon Smith-Njigba To Record 90+ Receiving Yards (-152)

Buffalo Bills (7-4) @ Pittsburgh Steelers (6-5) - 4:25PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Buffalo Bills-178-3.0 (-115)O45.5 (-110)
Pittsburgh Steelers+150+3.0 (-105)U45.5 (-110)

This was a tough call because the Bills kind of usually have the Steelers’ number, but Mike Tomlin has the best ATS record as a home underdog (22-8-3) of anyone in football. But while we think Coach T will be able to get a cover here, those spreads can get tricky, so we went another route.

No offense to Aaron Rodgers and his tough-as-nails wrist, but Pittsburgh is going to run the ball on Sunday. The Bills have allowed 140 rushing yards per game over the last five weeks, seventh-most in the NFL. They have also given up 118.4 rush yards a game to RBs this season, third-most in the NFL. Woody Marks, Sean Tucker, and De’Von Achane have all had big days against this defense over the last three weeks.

Jaylen Warren and the Steelers are up next in line to take advantage. Warren has had 60+ yards in five of his last six games, and that included one where he missed most of the second half due to injury. He’s good to go now, though, and he should see a ton of run considering Buffalo’s struggles and Rodgers’ wrist.

Best Bet: Jaylen Warren To Record 60+ Rush Yards (-136)

Las Vegas Raiders (2-9) @ Los Angeles Chargers (7-4) - 4:25PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Las Vegas Raiders+440+9.5 (-110)O40.5 (-110)
Los Angeles Chargers-590-9.5 (-110)U40.5 (-110)

We look to L.A.’s surprising star running back this season for our pick in this game. No, not free agent signee Najee Harris or highly-touted rookie Omarion Hampton: it’s 2024 sixth-round pick Kimani Vidal. And he’s been on a tear—well, kind of.

Vidal had a terrible game last week, but so did everyone on the Chargers. Since he’s been in charge, Vidal has seen a 72 percent snap share, and more importantly, his 18 red zone carries represent a 90 percent share in that area, one of only three RBs that can meet that mark during this time.

Add in the fact that the Raiders have given up 11 rushing TDs to running backs this year, tied for fourth-most in football, and you’ve got a recipe for a bounce back from Vidal. Vidal has had two bad games as the starter before, and he bounced back a week later with 90+ yards and a TD both times. We expect the same reaction here.

Best Bet: Kimani Vidal Anytime Touchdown Scorer (-125)

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Alex Murray has been a consistent presence on BettingTop10 since he joined the team in 2020 just after graduating from Ryerson University’s Sport Media program in 2019. He has written for publications including theScore, Sporting News, FanSided, FantasyPros, and more over his 6+ years in the field. Alex has also been a lifelong athlete and sports fan who has channeled that love into his entertaining writing style and shrewd betting strategies.