Arizona Cardinals vs Los Angeles Rams: NFL Predictions, Odds & Picks | Week 10

Sunday, November 15, 2026 · 4:05 PM ET · State Farm Stadium, Glendale, AZ · CBS

Odds courtesy of Bet365, correct at time of writing and subject to change.

Arizona was held to just 3 points in a 17-3 loss at Seattle last week, a tough way to arrive at a divisional game against the Rams that the Cardinals won back in October. The Rams have won three of their last four games and sit 5-4, favoured by 9.5 points or more in this game on both Bet365 and Sports Interaction. That gap between this season's form and the head-to-head result is one of the sharper angles in NFL picks for this week.

Arizona Cardinals +9.5: -111

I'm backing the Cardinals to cover here. Arizona beat this Rams team 18-16 in Los Angeles back in Week 6, and I don't think a line now sitting at 9.5 points fully accounts for that head-to-head result. Two of the Rams' five wins this season have come by seven points or fewer and they were not overly impressive in their last game in a 7-point win over a Washington team that came into the contest with two wins. A 9.5-point cushion is a lot to ask the Rams to cover against a team they already lost to this season.

Odds from Bet365 and Sports Interaction, correct at time of writing and subject to change.

The Arizona side

With Jacoby Brissett being traded and Gardner Minshew lost for the season with an injury, rookie Carson Beck will get the start in this game. While it is his first career start he knows big game pressure playing for Georgia in college. The Cardinals are averaging 19.8 points a game while allowing 28.3, numbers that explain a 3-6 record heading into Sunday. Their  most recent loss at Seattle was the lowest point total of Arizona's season, but it followed an overtime win in Dallas the week before. The Cardinals’ defense has been up and down this season but they have a decent pass defense and played well on that side of the ball in the win over L.A. this season. 

The Los Angeles side

Matthew Stafford leads an offence averaging 23.8 points a game. The Rams are allowing 20.1 ppg, the better defence of the two teams in this matchup. Los Angeles has won three of its last four, including a 20-13 win at Washington last week. Arizona is still the one team already sitting on Los Angeles's schedule with a win this season, though, which is why I'm not comfortable backing the Rams to cover a number this big. Also, Stafford’s main target in star WR Puka Nacua is out for this game on IR.

Bet365	Sports Interaction
Cardinals -9.5	Under 39 points
-111	-110
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Bet365 and Sports Interaction odds, correct at time of writing and subject to change.

Sports Interaction's moneyline odds imply a de-vigged win probability of 79% for Los Angeles against 21% for Arizona. My own number sits closer to 75-25, a modest shift toward the Cardinals because they beat the Rams in L.A. this season. I think the market is underweighting that result even with Arizona going to a rookie QB, which is the real edge behind the spread I'm backing rather than the moneyline alone.

I'm leaning Rams by a touchdown, not by double digits. Arizona needed overtime to beat Dallas two weeks ago, but that shows a team capable of grinding out a close game rather than folding against a good opponent. Playing at State Farm Stadium gives the Cardinals an advantage they didn't have in the first meeting. A 24-17 final clears the 39-point total by two and has Arizona covering the 9.5-point spread.