Las Vegas Raiders vs Seattle Seahawks: NFL Predictions, Odds & Picks | Week 10

Sunday, November 15, 2026 · 4:05 PM ET · Allegiant Stadium, Las Vegas, NV · CBS

Odds courtesy of Bet365, correct at time of writing and subject to change.

Seattle is a 6.5-point road favourite even though Drew Lock, not Sam Darnold, will get the start. Darnold remains out with quadriceps and rib injuries, and his absence shapes this week's NFL picks for this week between two teams a game apart in the standings. Las Vegas is 4-5 and has lost four of its last five, while Seattle sits at 5-4 behind a defence that held the Chiefs and the Cardinals to three points apiece in two of its last three outings.This will be the first we see of #1 pick Fernando Mendoza since the Raiders traded Kirk Cousins to Minnesota.

Seattle Seahawks -6.5: -111

I'm backing the Seahawks to cover here. Seattle's defence has been great in two of the last three games and even with a banged up offensive line Drew Lock has shown he can be a viable backup. Also, Seattle will be facing a rookie QB in Mendoza making his first career start and will also be facing a Las Vegas scoring defence that ranks dead last in the league.

Odds from Bet365 and Sports Interaction, correct at time of writing and subject to change.

The Las Vegas side

Las Vegas has lost four of its last five games, including a  17-38 defeat at San Francisco this past Sunday that extended its own four-game slide. Mendoza gets the start and while the Raiders had a good passing offense with Cousins the team only ranks 31st in rushing yards per game. On top of that they have the worst defense in the league giving up an average of 29.8 ppg. 

The Seattle side

Seattle enters off a 17-3 win over Arizona, a game Drew Lock started in place of Darnold, who remains out and isn't expected back before the team's Week 11 bye. Seattle's defence did the heavy lifting in that one, the same unit that has now held two of its last three opponents to three points. Left tackle Charles Cross and guard Quenton Nelson are both doubtful, adding real protection risk in front of Lock, who is himself questionable with an oblique injury but expected to play. Seattle still has the far stingier defence in this matchup, allowing 18 ppg against 29.8 ppg for Las Vegas, and that gap is the actual reason this line sits at 6.5 rather than something smaller.

Bet365	Sports Interaction
Seahawks -6.5	Over 40.5
-111	-110
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Bet365 and Sports Interaction odds, correct at time of writing and subject to change.

Seattle's moneyline odds of -294 on Bet365 imply a de-vigged win probability of 71% for the Seahawks against 29% for Las Vegas. That value sits pretty well with me with Lock a little banged up but the Raiders also starting a rookie QB and having a porous defence. Take the Seahawks to win and over in this one. 

I predict a 30-17 Seattle win. Las Vegas's defence has allowed 30 or more points in each of its last five games and look for that to continue even with Lock getting the start. That score clears the Seahawks 6.5 point spread and lands the total over Bet365's 40.5 line.