NFL Pick 6: Week 1 6-Leg, 6-Point Teaser Parlay

The NFL is back after a long and hard wait, and Week 1 has a juicy slate for us this weekend. You can bet on these games in a lot of ways. You can bet on totals or player props. You can go moneyline or point spread.

Or you can go with a teaser parlay. In a teaser parlay, every leg adds the same amount of points to the spread for the team you’re picking, to give you a little cushion and make you feel safe. For our purposes, we’re going with a six-leg, six-point teaser for Week 1 that gives us +600 odds!

NFL Pick 6: Week 1 6-Leg, 6-Point Teaser Parlay

All odds provided by Sports Interaction.

• (A) Arizona Cardinals -6.5 Spread → -0.5
• (A) Cincinnati Bengals -5.0 Spread → +1.0
• (A) Miami Dolphins -1.0 Spread → +5.0
• (H) Washington Commanders -6.0 Spread → Even
• (A) San Francisco 49ers -1.0 Spread → +5.0
• (H) Denver Broncos -8.5 Spread → -2.5
• Parlay Odds: +600

Arizona Cardinals (-6.5) @ New Orleans Saints - 1PM

The Cardinals are going to be competitive this season. The Saints are not. Simple as that. We already thought this -6.5 point spread that betting sites are giving Arizona was crazy low, so the red birds were a guarantee for our first 6-point teaser of the year.

Teaser Pick: Arizona Cardinals (-0.5)

Cincinnati Bengals (-5.0) @ Cleveland Browns - 1PM

Cincinnati didn’t do enough to improve their defense for our liking. But they definitely did enough to beat the downtrodden Browns. Let’s not forget that Cleveland QB Joe Flacco is 41 years old. There’s no way Joe Burrow loses a duel to him at this point in his career.

Teaser Pick: Cincinnati Bengals (+1.0)

Miami Dolphins (-1.0) @ Indianapolis Colts - 1PM

We’re pretty low on the Dolphins going into the 2025 season, but we’re even lower on the Colts. And how could we not be. They had Daniel freaking Jones win their QB battle during the offseason and they lost 2/5 of their elite offensive line as well. The Dolphins are healthy enough right now to make this a blowout win, so they surely won’t lose by more than a field goal.

Teaser Pick: Miami Dolphins (+5.0)

New York Giants @ Washington Commanders (-6.0)  - 1PM

We think Washington should be much bigger favorites at home here against the division-rival Giants. Apart from an elite defensive line, there’s not much to write home about concerning Big Blue. A straight up bet on this game is a no-brainer.

Teaser Pick: Washington Commanders (ML)

San Francisco 49ers (-1.0) @ Seattle Seahawks - 4:05PM

This will actually be one of the toughest games on the 49ers’ schedule in 2025, but we think they should still win it. Even without Christian McCaffrey. We’ve seen guys like Jeff Wilson and Isaac Guerendo come out of nowhere and do well in that offense, so as long as Brock Purdy and Trent Williams are there, the 49ers should be good.

Teaser Pick: San Francisco 49ers (+5.0)

Tennessee Titans @ Denver Broncos (-8.5) - 4:05PM

Going up against what is being touted as the best defense in football going into the 2025 season (the Broncos) is not an ideal way to start out your NFL career if you’re Titans No. 1 overall pick Cam Ward. But that’s what he’ll have to do. And at Mile High as well. This one could get ugly for the former Hurricanes QB.

Teaser Pick: Denver Broncos (-2.5)/Sports Interaction