Broncos vs. Raiders Week 10 TNF: NFL Betting Odds & Picks

The divisional rivalry theme of this year’s Thursday Night Football slate continues in Week 10 with the 7-2 Denver Broncos, who sit atop the AFC West, hosting the 2-6 Las Vegas Raiders, who dwell at the bottom of said division.

Denver has needed a few wild comebacks to get to where they are, however, so could the Raiders complete the upset at Mile High on Thursday night? Read on for our point spread predictions as well as our favorite player prop and the best NFL betting odds in Canada!

2025 TNF Best Bets Record: 12-17 (-7.17)

Note: None of our best bets feature odds shorter than (-200).

NFL Week 10 TNF: Denver Broncos (7-2) vs. Las Vegas Raiders (2-6) Odds & Picks - Nov. 6

All odds provided by Sports Interaction.

Broncos vs. Raiders Point Spread/Moneyline Prediction

The Raiders came back off of their bye last week and lost an OT thriller to the Jaguars 30-29 after failing to hit on a ballsy two-point conversion. As if they weren’t already in bad enough spirits. The Broncos, meanwhile, pulled off yet another improbable comeback, this time beating the Texans 18-15 on a last-second field goal.

This has been an interesting fixture over the past few years: the Raiders won eight straight against Denver from 2020-2023, but the Broncos with the new Sean Payton-Bo Nix combo got a clean sweep last year, covering the spread both times and winning by double digits.

This time around, it feels like if the Broncos can stop Brock Bowers, it’ll be a blowout. Ashton Jeanty is another consideration, but he’s struggled to find room on the ground, and the Broncos have a top run defense that allows just 3.7 yards a carry, fourth-best in football. The Broncos have been pretty good at slowing opposing TEs this year, allowing just over four receptions a game to them, sixth-fewest in football.

Vegas’ defense won’t be of any help: they’ve given up 25+ points in five of six games, with the only one under that number coming against the lowly Titans. They’ve been blown out by 17+ in three of their last six games, including a 31-0 loss to another divisional rival in the Chiefs. Chalk up another blowout loss for the Raiders.

Prediction: Denver Broncos -8.5 Point Spread (-110)

Broncos vs. Raiders Player Prop Best Bets

J.K. Dobbins remains the focal point of the Broncos’ rushing attack. And that’s especially true in the red zone. He has 19 carries inside the red zone this year compared to just five for rookie R.J. Harvey. And that has remained consistent throughout the season so far: over the last month, Dobbins has the edge 6-2, which represents a similar 75 percent share.

Dobbins has not scored since October 5, but he’s been playing very well and he did score four times in the first five weeks. So that nose for the end zone is there. And he’s got a great matchup here on Thursday to get him back to the promised land.

The Raiders have allowed 12 rushing TDs in eight games this year, second-most in the NFL. They have allowed nine to RBs specifically, including at least one in five of their last six games, with the lone holdout once again being that win over the Titans.

Best Bet:

• J.K. Dobbins Anytime Touchdown Scorer (-120)