The St. Louis Cardinals will be looking to bring out the brooms on Sunday, June 22, when they host the Cincinnati Reds in the rubber match of a three-game set. The first pitch is scheduled for 2:15 PM EDT at Busch Stadium. The Cards have won the first two games of this series, pulling out a 6-5 victory on Saturday. They’re currently riding a five-game winning streak heading into the finale. Continue reading for the Reds vs Cardinals betting picks.
MLB: Reds vs Cardinals Odds, Analysis, & Picks

Photo courtesy of Minda Haas Kuhlmann (Flickr), CC by 2.0
Highlights
- The Reds and Cardinals wrap up a three-game set on Sunday
- St. Louis is looking for the sweep
- Continue reading for the odds, preview, and picks
Odds provided by Sports Interaction.
Reds vs Cardinals Odds
Moneyline | Reds -115 | Cardinals -105 |
Total Runs | Over 9.5 (-102) | Under 9.5 (-118) |
There’s no clear favorite here. The Reds sit at -115 odds, while the Cardinals return at -105. MLB betting sites. The total sits at 9.5 runs, and the Over cashed in Saturday’s clash, with St. Louis winning 6-5.
The Cardinals are 4-1 so far this season against Cincinnati.
Reds vs Cardinals Analysis
The National League Central is extremely tight, and the Reds remain in the mix. While they’re 7.5 games out of first place, Cincy’s 39-38 record has them in contention for a Wild Card spot. But, there is still a lot of time left in the campaign to either improve or go downhill. The Reds possess a respectable offense, ranking 10th in the big leagues in runs scored with 4.6 per game while sitting 16th in team average. On the mound, they’re around the middle of the pack, boasting a 3.90 team ERA.
Cincy will be hoping the dominant Andrew Abbott can help them end a three-game losing skid here. The righty has been lights out in 2025, going 6-1 with a 1.84 ERA in 12 starts. He’s struck out 69 hitters in 68.1 innings of work while walking just 20 batters. Abbott is looking like one of the best pitchers in the Majors so far, and his ERA is even lower on the road, sitting at 1.45. The Reds will be feeling very confident with their ace on the hill. He’s yet to face the Cardinals this season.
The Cardinals have been one of the most surprising teams in the show. Many believed they’d be a disaster after focusing on the youth movement, but as things stand, St. Louis could very well make the postseason. Oli Marmol’s group is 42-35 and, as previously mentioned, will be seeking their sixth consecutive victory on Sunday and their second straight series sweep. The Cards brought out the brooms against the Chicago White Sox earlier this week. Offense is the clear strength for St. Louis, ranking top six in runs, hits, and average. Pitching, meanwhile, is their biggest weakness.
Miles Mikolas gets the ball in the rubber match, and he’s struggled this year. The veteran has a 4-4 record and 4.36 ERA in 14 starts, striking out a mere 45 hitters in 72.1 frames. On a more positive note, he’s only walked 18. Mikolas is just getting hit around. He’s allowed at least two earned runs in each of his last four appearances. Unfortunately, his ERA balloons to 5.01 at home. Not great news ahead of the finale.
Reds vs Cardinals Picks
I have the utmost confidence in how Abbott is throwing the baseball at the moment. Also, this Reds lineup has raked against Mikolas, hitting .308 across 108 at-bats. The Reds will salvage a win here and avoid the sweep versus a divisional rival.
Quinn Allen is a seasoned sports journalist from Vancouver, Canada. Quinn is a full-time senior editor for ClutchPoints where he specializes in baseball, soccer, basketball, and football. Quinn has been working in the industry for five years and brings a unique outlook to sports journalism, having played high-level soccer and baseball growing up. Quinn resides in Kelowna, Canada, and enjoys playing soccer and going to the gym.

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