Detroit Lions vs New England Patriots: NFL Predictions, Odds & Picks | Week 10

Sunday, November 15, 2026 · 9:30 AM ET · Allianz Arena, Munich, Germany · FOX

Odds courtesy of Bet365, correct at time of writing and subject to change.

Detroit's offence has scored at least 19 points in eight straight games this season, part of why the Lions sit 6-2 heading into this trip to Munich's Allianz Arena. New England arrives off a 45-27 loss to Green Bay, and that scoring gap is the main reason Detroit opened as a clear favourite in this week's NFL picks for Week 10.

Detroit Lions -2.5: -120

I'm backing the Lions to cover here. Detroit is hot winners of four in a row, while New England just conceded 45 points to Green Bay and arrives in Germany with questions at receiver. Detroit's defence has allowed more than 23 points just three times in eight games, and New England's offence has topped 27 points only three times in nine games. That gap between the two sides is why I like Detroit -2.5 on Bet365.

Odds from Bet365 and Sports Interaction, correct at time of writing and subject to change.

The Detroit side

Jared Goff and the Lions are averaging 27.8 points across eight outings while allowing 23.6. Detroit's four-game winning streak includes a 19-9 win over Miami last week. The Lions are rolling and while they were not overly impressive on the offensive side of the ball last week they face a Pats team that gave up 45 points in their last game. Goff and company on the offensive side of the football is why we like the Lions across the pond. 

The New England side

New England is 5-4 after a 45-27 loss to Green Bay, a game in which the defence allowed a season-high 45 points. A.J. Brown has yet to make a splash this season as the team’s big off-season acquisition. The Patriots have lost two of their last three games and have not strung together consecutive wins since Weeks 5 and 6. They head into Munich with a lot of questions marks facing a streaking Lions team.

Bet365	Sports Interaction
Lions -2.5	Lions Moneyline
-120	-160
Bet Safety Net Up To C$1,000 or Bet C$10 and Get C$50 in Bonus Bets	125% Welcome Bonus Up To C$750
Bet Now	Bet Now

Bet365 and Sports Interaction odds, correct at time of writing and subject to change.

Bet365's -159 line on Detroit implies a de-vigged win probability of 59% for the Lions against 41% for New England. I estimate it higher, around 63%, because the market isn't fully pricing how much the NewEngland defense struggled in their last game and now facing a Detroit scoring offence that ranks 5th in the league. 

I'm backing a 30-23 Lions win that clears Bet365's 51.5 total and gives Detroit more than the 2.5-point cushion it needs to cover. New England's offence has topped 27 points only three times in nine games, and matching Detroit's pace through the air alone is the tougher path. I predict Detroit covers while the total clears 51.5 in what looks to be an exciting non-conference matchup.