NFL Pick 5: Week 10 5-Leg, 6-Point Teaser Parlay

Alex Murray
By: Alex Murray
Nov 07, 2025
NFL Picks
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Nearly every week we put out our “Pick 6” parlay featuring six picks on a six-point teaser, we miss by just one game. We’ve hit one parlay perfectly, gone 4-2 on a couple, and 5-1 on the other five. It’s time to make a change and see what shakes out. We’re reducing our parlay to five picks while retaining the six-point teaser format. So without further ado, check out our winners for Week 10 in the NFL!

2025 Pick 6 Teaser Parlay Record: 1-7 (-1.00)

2025 Pick 6 Teaser Picks: 37-11

Highlights

  • Josh Allen is 5-1 at Miami since 2019, winning by an average of 16.6 points
  • Chicago has won 5 of 6 while scoring 25+ in each of those wins
  • Seattle’s top 5 pass offense will have a big day against Arizona’s bottom 10 pass defense

NFL Week 9 Pick 6: 6-Leg, 6-Point Teaser Parlay

All odds provided by Sports Interaction.

  • (A) Buffalo Bills -9.5 Spread → -3.5
  • (H) Carolina Panthers -5.5 Spread → +0.5
  • (H) Chicago Bears -4.5 Spread → +1.5
  • (H) Seattle Seahawks -6.5 Spread → -0.5
  • (A) Detroit Lions -8.0 Spread → -2.0
  • Parlay Odds: +333

Buffalo Bills (-9.5) @ Miami Dolphins - 1PM

Last time these two teams met on TNF, the Dolphins actually played the Bills pretty tough. The Dolphins covered the spread, but it was 12 points, and they lost by 10. This time around, they will be without Tyreek Hill with the Bills looking to make it three straight wins following their bye.

Josh Allen and company are coming off a big victory over the Chiefs, their fourth straight over K.C. in the regular season. In the week following those last three wins over their nemesis, the Bills have won by 10, 21, and 25, covering the spread each time. Allen has also gone 5-1 at Miami since 2019, winning by an average of 16.6 points. They should be able to cover 3.5 here.

Teaser Pick: Bills (-3.5)

New Orleans Saints @ Carolina Panthers (-5.5)  - 1PM

Who would have thought that come November, the Panthers would have a real chance to go 6-4? But that’s exactly the situation we’re in, and Bryce Young is back in the lineup for Carolina. And that means there was no chance we weren’t gonna take the Panthers at home here: Young is just 3-17 on the road in his career, but he’s 8-10 at home. Not a trend to ignore.

Carolina beat the Saints team at home 23-22 last year, and while the Panthers are a much better team than in 2024, the Saints are much worse. New Orleans has covered just one of their eight underdog spreads this season, and since their surprise win over the Giants in Week 5, they have lost by 6, 12, 20, and 24. With sports betting sites offering Carolina’s spread at under six points, we couldn’t resist basically getting Young and the gang on the moneyline for this parlay.

Teaser Pick: Panthers (+0.5)

New York Giants @ Chicago Bears (-4.5) - 1PM

The Giants had a fun few weeks there with Jaxson Dart and Cam Skattebo running roughshod over their opponents. But since Skattebo went down a couple of weeks ago, the Giants have simply not looked as inspired. They lost the game in which Skattebo was hurt 38-20, and a severely injured-plagued 49ers team beat them by 10 last week.

They have struggled on the road as well. Their last three away games have been: giving the Saints their only win of the year (and by 12 points no less), choking away a 19-0 fourth quarter lead to the Broncos, and that butt-kicking at the hands of the Eagles. Meanwhile, the Bears have won five of six while putting up 25+ in each of their wins. Big Blue has scored 24 or fewer in four of their last six.

Teaser Pick: Bears (+1.5)

Arizona Cardinals @ Seattle Seahawks (-6.5) - 4:05PM

The Cardinals got a surprise win over the Cowboys in prime time last week with Jacoby Brissett at the controls. And that was a fun night for them. Brissett has always been a solid backup. But there’s a reason he’s a backup.

The 32-year-old QB has struggled to move around and escape pressure, and that will be a problem against a Seattle front that has racked up 27 sacks this season, tied for third-most in the league. Arizona’s bottom 10 pass defense is also likely to struggle against Seattle’s top five passing attack.

Teaser Pick: Seahawks (-0.5)

Detroit Lions (-8.0) @ Washington Commanders - 4:25PM

The Lions suffered a brutal upset at the hands of the Vikings last week, so we’re expecting a big bounce back performance from this talented team. They lost their season opener this year, then whooped the Bears 52-21 the next week.

They lost a rough one to the Chiefs in prime time a few weeks ago and came back with a 24-9 win over the Buccaneers the week after. With Marcus Mariota at the controls for the Commanders here, this one is likely to get out of hand in Detroit’s favor as well.

Teaser Pick: Lions (-2.0)

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Alex Murray has been a consistent presence on BettingTop10 since he joined the team in 2020 just after graduating from Ryerson University’s Sport Media program in 2019. He has written for publications including theScore, Sporting News, FanSided, FantasyPros, and more over his 6+ years in the field. Alex has also been a lifelong athlete and sports fan who has channeled that love into his entertaining writing style and shrewd betting strategies.