Los Angeles Rams vs Arizona Cardinals: NFL Predictions, Odds & Picks | Week 6

Sunday, October 18, 2026 · 4:05 PM ET · SoFi Stadium, Inglewood, CA · FOX

Odds courtesy of Bet365, correct at time of writing and subject to change.

Los Angeles is 2-3 after an overtime loss at Buffalo last week, but the team with the best odds to win the Super Bowl this season still has the top passing attack and their last two losses have been close facing solid teams. The Rams won both of last season's meetings between these NFC West rivals by a combined 45 points, and that history lines up with the huge 12.5-point spread Bet365 has posted for Sunday's game. That number shapes this week's NFL prediction Week 6 pick.

Los Angeles Rams -12.5: -111

I'm backing the Rams to cover this number. Arizona's defence ranks 26th in total yards allowed and 23rd against the run, and its offence is averaging only 21.6 ppg behind Jacoby Brissett, who is protected by a line that has already allowed 12 sacks. Los Angeles still has Matthew Stafford and a defense that is getting healthier and the team beat the Cardinals 45-17 and 37-20 the last two times these teams met. A 12.5-point line against a team this banged up on defence is where I see the value.

Odds from Bet365 and Sports Interaction, correct at time of writing and subject to change.

The Los Angeles side

The Los Angeles side has lost two of its last three games, including a 37-34 overtime loss to Buffalo, but the underlying defensive numbers hold up: the Rams have allowed just 285.2 yards a game, third in the league, and they rank sixth on third down at 32.8%. Matthew Stafford carries the offence, giving him a full complement of targets in Puka Nacua and Davante Adams. Los Angeles is 1-2 at home this season, but the Rams have won the last two meetings with Arizona by a combined 45 points, and that trend carries more weight here than the home record.

The Arizona side

The Arizona side is 1-4, last in the NFC West, and has been outscored 162-108 this season. Jacoby Brissett has started every game behind an offensive line that has already allowed 12 sacks, and Arizona ranks 23rd against the run and 25th against the pass. The defence has surrendered at least 30 points in three of its five games, including a 45-21 loss to Detroit last week, and that pattern is exactly why I expect Los Angeles to move the ball freely again on Sunday.

Bet365	Sports Interaction
Rams Moneyline	Rams Spread
-909	-12.5 (-110)
Bet Safety Net Up To C$1,000 or Bet C$10 and Get C$50 in Bonus Bets	125% Welcome Bonus Up To C$750
Bet Now	Bet Now

Bet365 and Sports Interaction odds, correct at time of writing and subject to change.

Bet365's own number implies an 86% win probability for Los Angeles against 14% for Arizona, and I don't think that is far off. I'd nudge the Rams up slightly to 88%, given how one-sided this series has been inside the division in the last few seasons. The Cardinals are already priced as heavy underdogs here, so there is no hidden gap: the market has largely got this mismatch right, with the public money still backing L.A. even giving 12.5 points.

Last 5 Games: Los Angeles Rams

Last 5 Games: Arizona Cardinals

I'm backing Los Angeles to win 34-20. Rams RB Kyren Williams gets a Cardinals run defence that has already allowed 633 yards through five games, and I expect the Rams' red-zone offence, which converts at 65%, ninth in the league, to cash in more of its trips than Arizona's defence allows. Arizona's offensive line has surrendered 12 sacks and I expect the Rams' pass rush to add to that number on Sunday. The 54-point combined total clears the 51.5 line, and the 14-point margin covers the 12.5-point spread.