New Orleans Saints vs Carolina Panthers: NFL Predictions, Odds & Picks | Week 10

Sunday, November 15, 2026 · 1:00 PM ET · Caesars Superdome, New Orleans, LA · FOX

Odds courtesy of Bet365, correct at time of writing and subject to change.

New Orleans and Carolina are both 3-5 when they meet at the Caesars Superdome on Sunday. It is a NFC South matchup between two teams heading in different directions and a game where first place in the division is at stake. I like the short 2.5-point spread for the home team in this division battle.

New Orleans Saints -2.5: -111

New Orleans -2.5 is the play. Bet365's own moneyline number implies a cleaner favourite than the 2.5-point spread suggests, and the Saints bring recent head-to-head success into this one too, having taken the last two meetings with Carolina, including a 20-17 home win last season. 

New Orleans is the more complete team on paper right now, and I'd rather lay the 2.5 at home than take the plus-money underdog on the road.

Odds from Bet365 and Sports Interaction, correct at time of writing and subject to change.

The New Orleans side

New Orleans is coming off a 23-22 overtime win over Cleveland, with Tyler Shough throwing the game-winning touchdown pass and finishing 21 of 35 for 265 yards. The Saints are averaging 23.1 ppg while allowing 27.0 ppg, numbers that undersell a defence that has tightened up since the Week 8 bye. New Orleans has won two of its last three games, a step up from the stretch that preceded it and they are in better form than the reeling Panthers. 

The Carolina side

Carolina arrives on a three-game skid, outscored 96-53 in losses to Tampa Bay, Green Bay and Denver. Bryce Young played through a Week 9 ankle issue in that loss to Denver and remains the starter. Carolina is averaging 24.9 ppg but allowing 27.4 ppg, with the defence the bigger issue through eight games.

Bet365	Sports Interaction
Saints -2.5	Saints Moneyline
-111	-145
Bet Safety Net Up To C$1,000 or Bet C$10 and Get C$50 in Bonus Bets	125% Welcome Bonus Up To C$750
Bet Now	Bet Now

Bet365 and Sports Interaction odds, correct at time of writing and subject to change.

Saints moneyline odds of -141 on Bet365 imply a de-vigged win probability of 56% for New Orleans against 44% for Carolina, one of the tighter NFL prediction odds on this week's slate. My number sits a little higher, around 59%, and I think the gap comes down to form: New Orleans has played much better over its last three games than Carolina has. It should stay a lower-scoring game either way, with both offences in the low-to-mid 20s this season, but the Saints have the better matchup on both sides of the ball in this game. 

I'm backing New Orleans to win the game 26-20 in one that stays closer to the spread than the moneyline implies. Carolina has topped 25 points only once in its last five games, which caps my total projection below the 48.5-49 line posted on both sportsbooks. New Orleans' offence should benefit from confidence in winning two of their last three games. The 26-20 result clears the 2.5-point spread and stays under the total.