Tennessee Titans vs Jacksonville Jaguars: NFL Predictions, Odds & Picks | Week 10

Sunday, November 15, 2026 · 1:00 PM ET · Nissan Stadium, Nashville, TN · FOX

Odds courtesy of Bet365, correct at time of writing and subject to change.

Jacksonville is 6-2 and fresh off a 33-10 road win over Baltimore on Thursday night, with ten days to prepare before this AFC South clash. Tennessee is 1-7 and has not played since a 43-36 overtime loss at Cincinnati on November 1, returning from its bye losing two in a row where they gave up a total of 70 points. The gap between these two rosters shows up everywhere in the numbers below, and it’s the main reason Jacksonville is the biggest favourite on this week's NFL prediction odds board.

Jacksonville Jaguars -10.5: -109

I'm backing Jacksonville to cover here. The Jaguars rank 4th in the league at 28.6 ppg and 2nd in points allowed at 15.1 ppg, while Tennessee sits 28th in scoring at 18 ppg and 22nd on defence at 24.9 ppg allowed. That gap is about as wide as it gets between two teams meeting in Week 10, and the Jags have won four of its last five games. My read is the market has the favourite right but is undervaluing the final margin.

Odds from Bet365 and Sports Interaction, correct at time of writing and subject to change.

The Titans side

Cam Ward remains the starter for a weak Titans’ offence and he only ranks 22nd in the league in QBR. The lone win for Tennessee this season came against Indianapolis, which ranks 30th in the league in points allowed and has lost five in a row. Three of the four losses in the last five games were decided by one score, including the 43-36 overtime defeat to Cincinnati, and the exception was a 26-3 blowout loss to Houston, evidence Tennessee can hang in games but still has not found a way to finish. 

The Jaguars side

Trevor Lawrence has enjoyed a solid season ranking ninth in QBR and he has only tossed four picks. The Jaguars have won five of their last six, including a 33-10 road win over Baltimore on Thursday night in their last game. That stretch also includes a one-score road win at Cincinnati, a 6-2 team in its own right, with the only loss in that span coming against Houston. Four wins by a combined 65 points over that stretch is why I like Jacksonville to cover a number this size even on the road.

Bet365	Sports Interaction
Jaguars Moneyline	Under 46 points
-588	-110
Bet Safety Net Up To C$1,000 or Bet C$10 and Get C$50 in Bonus Bets	125% Welcome Bonus Up To C$750
Bet Now	Bet Now

Bet365 and Sports Interaction odds, correct at time of writing and subject to change.

Jacksonville's -588 moneyline on Bet365 implies an 82% win probability after removing the vig, against 18% for Tennessee. My own number sits close to that, around 84%, so this is a case where the market is largely efficient and my edge is in bet selection rather than the winner. The Jaguars' defence, 2nd in the league in points allowed, draws the NFL's lowest-scoring offence, and that matchup is the reason I like laying the double-digit number on the spread but staying away from the monyline. 

I'm backing a 30-13 final, a 17-point margin that clears the 10.5-point spread by  and settles under both the 46.5 total on Bet365 and the 46 number at Sports Interaction. Jacksonville gets ten extra days off its Thursday-night win, and the Jags already lead the AFC South outright while Tennessee sits last in the division. That gap in standings lines up with the one on the field, and I expect Jax to easily win this game and stay atop a division that they are running away with as the only one in it with a winning record.