NFL Week 10 Early 1PM Slate Betting Picks, Odds, & Best Bets

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We were a little uneven last week with a couple of near upsets by the Titans and Falcons thwarting out card. We’ll look to get back on the right side of things in Week 10 with the upcoming seven-game 1PM slate on Sunday. Read on for our best bets and analysis for each game as well as the top betting odds from the best Canadian betting apps!
2025 1PM Slate Best Bet Record: 37-29 (-1.26)
Note: None of our best bets feature odds shorter than -200.
Highlights
- Jacksonville has allowed a TE to hit their over in every single game this season
- Baltimore has allowed 200+ passing yards in all but one game this year
- The Saints are 1-7 ATS as an underdog in 2025
NFL Week 10 Early Sunday 1PM Betting Picks & Odds - November 9
All odds provided by Sports Interaction.
Jacksonville Jaguars (5-3) @ Houston Texans (3-5) - 1PM
| Team | Moneyline | Point Spread | Total (Over/Under) |
| Jacksonville Jaguars | -112 | -1.5 (-110) | O37.5 (-110) |
| Houston Texans | -104 | +1.5 (-110) | U37.5 (-110) |
The Jaguars have straight up not been able to stop opposing tight ends this season. They have allowed a TE to go over their receiving yards prop in every single game this season, including during the first meeting between these teams, when Dalton Schultz had 39 yards. His number is at 37.5 this time around, and we believe he’ll blow by that.
Best Bet: Dalton Schultz Over 37.5 Receiving Yards (-110)
New York Giants (2-7) @ Chicago Bears (5-3) - 1PM
| Team | Moneyline | Point Spread | Total (Over/Under) |
| New York Giants | +188 | +4.5 (-110) | O46.5 (-110) |
| Chicago Bears | -225 | -4.5 (-110) | U46.5 (-110) |
The Giants have been getting pummeled on the defensive end over the last few weeks, giving up 34, 38, and 33 during this current three-game losing streak. Meanwhile, the Bears have been scoring at will, especially against poor units like this Giants one. Chicago has gone for 25+ in five of their last six games.
Best Bet: Chicago Bears Over 25.5 Points (-135)
Baltimore Ravens (3-5) @ Minnesota Vikings (4-4) - 1PM
| Team | Moneyline | Point Spread | Total (Over/Under) |
| Baltimore Ravens | -230 | -4.5 (-110) | O48.5 (-110) |
| Minnesota Vikings | +190 | +4.5 (-110) | U48.5 (-110) |
With Lamar Jackson back in the fold, we expect the Ravens to be leading for much of this game. That sets up well for J.J. McCarthy to have the first 200+ passing yard game of his career. He’s gone for between 143 and 158 yards in his first three starts, but the Ravens still field a really bad pass defense. They’ve given up 200+ pass yards in all but one game, and 240+ in four of the last five.
Best Bet: J.J. McCarthy 200+ Pass Yards (-154)
Cleveland Browns (2-6) @ New York Jets (1-7) - 1PM
| Team | Moneyline | Point Spread | Total (Over/Under) |
| Cleveland Browns | -126 | -2.5 (-110) | O37.5 (-110) |
| New York Jets | +108 | +2.5 (-110) | U37.5 (-110) |
We can’t bet on either team in good conscience here. So we’re looking at something more specific: the Jets’ poor run defense. Quinshon Judkins returned from his AC joint sprain quicker than expected and is practicing in full this week. He should get the lion’s share of the carries against a unit that has allowed 120+ rush yards in six of the last seven games. New York is also allowing over 108 rush yards a game to RBs, seventh-most in the NFL.
Best Bet: Quinshon Judkins 80+ Rush Yards (-132)
New Orleans Saints (1-8) @ Carolina Panthers (5-4) - 1PM
| Team | Moneyline | Point Spread | Total (Over/Under) |
| New Orleans Saints | +205 | +5.5 (-110) | O38.5 (-110) |
| Carolina Panthers | -250 | -5.5 (-110) | U38.5 (-110) |
The Panthers have been one of the most pleasant surprises of the season, as they come in here with a chance to go to 6-4. The Saints are underdogs nearly every week (and for good reason), and nearly every week, they fail to even cover the spread, going 1-7 ATS as dogs this season. Don’t overthink this one. Roll with the Panthers.
Best Bet: Carolina Panthers -5.5 Point Spread (-110)
Buffalo Bills (6-2) @ Miami Dolphins (2-7) - 1PM
| Team | Moneyline | Point Spread | Total (Over/Under) |
| Buffalo Bills | -560 | -9.5 (-110) | O49.5 (-110) |
| Miami Dolphins | +420 | +9.5 (-110) | U49.5 (-110) |
Miami had a couple of good weeks stopping the run there, but the old Dolphins run defense was back last week, allowing Derrick Henry a 100-yard game. Now it’s James Cook’s turn. He went for 108 yards earlier in the year against the Dolphins, and he has gone for 85+ yards on the ground in six of the last seven games. That includes five 100+ yard games and even a 200-yarder a couple of years ago. Not to mention the Fins have allowed 140+ rush yards in six of seven games this year.
Best Bet: James Cook 80+ Rush Yards (-146)
New England Patriots (7-2) @ Tampa Bay Buccaneers (6-2) - 1PM
| Team | Moneyline | Point Spread | Total (Over/Under) |
| New England Patriots | +120 | +2.5 (-110) | O48.5 (-110) |
| Tampa Bay Buccaneers | -142 | -2.5 (-110) | U48.5 (-110) |
This is by far the most intriguing game on the docket here. Which also makes it the hardest to handicap. Considering it’s an inter-conference matchup, we like it to be a shootout. You’ve got arguably the top two MVP candidates at QB in this one. The Bucs have scored 23+ in five of their last six, while the Pats have scored 23+ in six straight. We’ll buy a few points on the total we’re getting from betting sites and take the over here.
Best Bet: Alternative Game Total Over 45.5 Points (-158)
T&Cs Apply
Alex Murray has been a consistent presence on BettingTop10 since he joined the team in 2020 just after graduating from Ryerson University’s Sport Media program in 2019. He has written for publications including theScore, Sporting News, FanSided, FantasyPros, and more over his 6+ years in the field. Alex has also been a lifelong athlete and sports fan who has channeled that love into his entertaining writing style and shrewd betting strategies.

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