NFL Week 4 Player Prop Best Bets, Picks, & Odds

Alex Murray
By: Alex Murray
Sep 26, 2025
NFL Picks
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There’s no ifs, ands, or buts about it, it’s been a tough start to the season for us when it comes to our player prop best bets. We have not had the dreaded 0-4 card, but we’ve come close a few times. But we’re of the mind that that only means we’re due for a bounce back week from these betting sites. So buckle up ladies and gentlemen, and read on for our quartet of player prop best bets across the NFL in Week 4.

2025 Player Props Best Bet Record: 3-9 (-6.27)

Highlights

  • The Bears have given up the second-most rushing yards to opposing RBs
  • Woody Marks has increased his workload significantly with each passing week
  • Hunter Henry has had 60+ yards in two of three games this season

NFL Week 4 Player Prop Best Bets & Odds

All odds provided by Sports Interaction.

Ashton Jeanty, RB, LV - Over 67.5 Rushing Yards (-110) vs. CHI

It’s been a frustrating start for the No. 6 overall pick. Ashton Jeanty has been getting a decent amount of touches, but the blocking in front of him has been atrocious. Even the best backs need a little bit of help. But what is encouraging is that he’s upped his yardage total in each week.

And considering the Raiders lost in blowout fashion in the last two games, that’s a good sign. Jeanty has also handled 78 percent of the backfield carries so far, so no worries about him losing opportunities.

On the other side, he gets the Bears defense. They have struggled mightily through the first three weeks, allowing the fourth-most points and yards in the NFL. They’ve been especially bad at stopping running backs, however. They are allowing 5.5 yards a carry, second-most in the NFL, and they’ve specifically allowed 363 yards on the ground to opposing RBs. Through three weeks, five different backs have hit the over on their rushing yards prop. Jeanty should make it six in Week 4.

Woody Marks, RB, HOU - Over 30.5 Yards (-110) vs. TEN

Some of you are probably wondering who the heck Woody Marks is. And to those people I say, fair enough. But it’s time to get familiar. The Texans’ fourth-round rookie out of USC has been slowly but surely taking the backfield away from veteran Nick Chubb. Marks has already removed Dare Ogunbowale from the conversation.

In Week 1, Marks played just seven snaps. In Week 2, that jumped up to 13, but still half as many as Chubb’s 26. However, in Week 3, Marks saw 30 snaps to Chubb’s 33, and he toted the ball six times compared to Chubb’s nine. Marks could overtake him in Week 4, though we have a feeling both backs will do well.

The Texans should be up for most of the game, and they’re facing off against the fourth-worst rush defense in the league in Tennessee. The Titans have allowed the third-most rushing yards to RBs this season. Jonathan Taylor torched them for 100+ last week, Blake Corum had a then-career high 44 in Week 2, and Kyren Williams, RJ Harvey, and JK Dobbins have all gone for 60+. Marks’ prop is not yet on the board, so we’re estimating it will jump to around 30 after it was at 16 last week.

Saquon Barkley, RB, PHI - Over 15.5 Receiving Yards @ TB

After running roughshod through the NFL last year en route to a historic season, Saquon Barkley has been largely held in check so far in 2025. He doesn’t have a 20-yard rush or a 100-yard game to his name yet. And it won’t get easier against the Buccaneers, who have the sixth-best run defense and are allowing just 3.6 yards a carry.

Tampa will also put points on the board, which will force the Eagles to pass the ball more than they might like to. So far this season, players catching passes out of the backfield have been the Bucs’ kryptonite. They are allowing over 70 yards per game through the air to opposing RBs through three games, most in the NFL.

They’ve allowed two RBs to go over Barkley’s 15.5-yard number in each of the last two weeks, and in Week 1, Bijan Robinson took six receptions for 100 yards against this Bucs defense.

Hunter Henry, TE, NE - Over 41.5 Receiving Yards vs. CAR

Carolina is allowing over 70 yards a game to opposing tight ends (most in the NFL), and while Kyle Pitts fell a couple of yards short last week, we like this matchup even more for Hunter Henry. He had that dud in Week 2 against Miami that’s kind of hard to explain, but he’s been one of the best TEs in football in the other two games.

In Week 1, he had 66 yards on eight targets in Week 1, and he had 90 yards on 11 targets last week against the Steelers. Trey McBride and Brenton Strange have both had solid games against this defense, so we like Henry to follow suit, especially at this small number.

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Alex Murray has been a consistent presence on BettingTop10 since he joined the team in 2020 just after graduating from Ryerson University’s Sport Media program in 2019. He has written for publications including theScore, Sporting News, FanSided, FantasyPros, and more over his 6+ years in the field. Alex has also been a lifelong athlete and sports fan who has channeled that love into his entertaining writing style and shrewd betting strategies.