NFL Week 15 Late Sunday 4PM Slate Best Bets & Betting Odds

Alex Murray
By: Alex Murray
NFL Picks
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CC0 1.0 Universal

Last week, Brock Bowers fell just a few yards short of another perfect week for us on the late slate. But we don’t blame you, Brock. We move. This week, we go jumbo.

For the first time in this 2025 NFL season, we get a big, fat five-game slate in the late West coast window in Week 15. We’ve got you covered with a best bet for each of those late afternoon contests, some of which have some very interesting playoff implications.

2025 Sunday 4PM West Coast Best Bets: 18-6 (+7.43)

Note: None of our best bets feature odds shorter than -200.

Highlights

  • Brian Robinson Jr. has rushed for 24+ yards in 5 straight games
  • The Lions have given up 1+ TDs to a WR in 11 of 13 games this year
  • Philip Rivers is 44 years old and playing his first game since 2021

NFL Week 15 Late Sunday 4PM Betting Picks & Odds - December 14

All odds provided by Sports Interaction.

Tennessee Titans (2-11) @ San Francisco 49ers (9-4) - 4:25PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Tennessee Titans+610+12.5 (-110)O44.5 (-105)
San Francisco 49ers-900-12.5 (-110)U44.5 (-115)

The Titans got a big win to double their total last week, but that’s likely going to be the last time they do that this year. The 49ers are 5-1 in the week after a bye over the last six years, they’re at home, they’re playing a team that’s competing for the top pick in the draft.

They should be in the lead for most of the game, or at the very least, not chasing. With Christian McCaffrey dealing with an illness and a back injury this week, we expect Brian Robinson Jr. to get a lot of overflow. He’s got 7+ carries and 24+ yards in each of his last four games. He could have his busiest day of the season this week.

Best Bet: Brian Robinson Jr. To Record 25+ Rush Yards (-154)

Detroit Lions (8-5) @ Los Angeles Rams (10-3) - 4:25PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Detroit Lions+215+5.5 (-105)O54.5 (-110)
Los Angeles Rams-260-5.5 (-120)U54.5 (-110)

It’s hard to ignore the Lions’ lack of pass defense in this one. They have allowed the most passing yards in the league over the last four weeks, and the eight TDs they’ve allowed over that span are second-most. Specifically, they have allowed 20 TDs to WRs this season, second-most in the NFL.

They have allowed a score to a wideout in 11 of 13 games this season, and Davante Adams is due for one after not touching pay dirt for the first time in nearly two months last week. Honestly, even if the entire Lions secondary wasn’t injured, we’d still take this Adams anytime TD prop as long as betting sites continue giving it to us under -200 odds.

Best Bet: Davante Adams Anytime Touchdown Scorer (-190)

Carolina Panthers (7-6) @ New Orleans Saints (3-10) - 4:25PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Carolina Panthers-162-2.5 (-110)O40.5 (-110)
New Orleans Saints+136+2.5 (-110)U40.5 (-110)

Rico Dowdle has hit 50+ yards in seven of his last nine games, and he has continued to see the bulk of the early down work even after Chuba Hubbard’s return.

The Saints have also been allowing over 150 rush yards per game over their last three. The Saints may win, but they won’t blow Carolina out. And as long as it’s tight or the Panthers have a lead, Dowdle should be in for a solid day’s work.

Best Bet: Rico Dowdle To Record 50+ Rush Yards (-152)

Green Bay Packers (9-3-1) @ Denver Broncos (11-2) - 4:25PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Green Bay Packers-122-1.5 (-110)O42.5 (-110)
Denver Broncos+104+1.5 (-110)U42.5 (-110)

Both teams have excellent defenses, but this line has been set low enough that we can take the over here if we buy a couple of points. The Packers have had six of nine games hit 40 points since their bye, and ditto for five of Denver’s last seven. It’s going to be a nice sunny day at Mile High, and we expect a surprising amount of points in a possible Super Bowl preview.

Best Bet: Alternative Game Total Points Over 40.5 (-160)

Indianapolis Colts (8-5) @ Seattle Seahawks (10-3) - 4:25PM

TeamMoneylinePoint SpreadTotal (Over/Under)
Indianapolis Colts+750+13.5 (-105)O41.5 (-110)
Seattle Seahawks-1,200-13.5 (-115)O41.5 (-110)

Philip Rivers has been all the rage this week. So of course we have a Rivers prop. At 44 years old and four years removed from his last NFL snap, it’s not that we doubt his mind or his resolve, but his body. There’s no way he’s not going to float one or short arm one or have a miscommunication with one of the receivers he’s known for about 12 minutes. The Seahawks are a tough team too, and the Colts will be chasing. A lot of opportunities for a Rivers interception.

Best Bet: Philip Rivers to Throw 1+ Interceptions (-176)

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Alex Murray has been a consistent presence on BettingTop10 since he joined the team in 2020 just after graduating from Ryerson University’s Sport Media program in 2019. He has written for publications including theScore, Sporting News, FanSided, FantasyPros, and more over his 6+ years in the field. Alex has also been a lifelong athlete and sports fan who has channeled that love into his entertaining writing style and shrewd betting strategies.