NFL Picks

Buffalo arrives at Allegiant Stadium off a wild overtime escape against the Rams, while Las Vegas is coming off a 45-17 blowout loss to New England. Both defences have been generous, Buffalo ranks 28th and Las Vegas 22nd in points allowed, setting up a Week 6 matchup that may be a barnburner.

The Kansas City Chiefs carry a perfect 4-0 record into Arrowhead Stadium against a Los Angeles Chargers team still searching for its first win, with the AFC West rivals meeting for the for the first time this season. The Chiefs’ offence is averaging 29.5 ppg, a sharp contrast with a Chargers’ unit managing just 16.8 ppg.

The 1-4 Arizona Cardinals travel to SoFi Stadium on Sunday riding a four-game losing streak, while the Los Angeles Rams look to bounce back from an overtime loss to Buffalo. A 12.5-point spread, among the widest on this week's board, puts both the margin and the total in play.

Pittsburgh heads to Tampa Bay on the back of a 34-22 win over Indianapolis, while the Buccaneers got their first win of the season in their last game behind Jalon Daniels with Baker Mayfield still sidelined by a thumb injury.

Carolina arrives at Lincoln Financial Field as a narrow road favourite after Philadelphia has dropped three straight games. To make matters worse, Philly QB Jalen Hurts is out for this NFC clash with a blood clot in his calf.

The New York Giants host the New Orleans Saints at MetLife Stadium on Sunday, with them atop the NFC East and New Orleans has lost three in a row and is searching for defensive answers after allowing 30-plus points in three of its five games

The Indianapolis Colts host a winless Tennessee Titans team on Sunday in this AFC South matchup, with Jonathan Taylor's ground game facing a Titans run defence that ranks 17th in the NFL in run defence.

New England carries a two-game winning streak over the Jets into Sunday's AFC East date at Gillette Stadium.New York has a bangled-up offensive line and is a low scoring team that faces a Patriots’ team that lit it up for 45 points in their last game.

Baltimore arrives at Huntington Bank Field off a 4-1 start and the league's 5th-ranked total offence, but Lamar Jackson's ankle injury has left his Week 6 availability unsettled heading into Sunday's AFC North matchup.

The Atlanta Falcons host the Chicago Bears in a Week 6 matchup between two teams both still in the playoff picture early on,in the season but the Falcons are still winless at home.